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Title: Drug therapies and delivery mechanisms to treat perturbed skin wound healing
Authors: Chin, Jiah Shin
Madden, Leigh
Chew, Sing Yian
Becker, David Lawrence
Keywords: Science::Medicine
Issue Date: 2019
Source: Chin, J. S., Madden, L., Chew, S. Y., & Becker, D. L. (2019). Drug therapies and delivery mechanisms to treat perturbed skin wound healing. Advanced Drug Delivery Reviews, 149-150, 2-18. doi:10.1016/j.addr.2019.03.006
Project: T1-002-098
T1-002- 013
Journal: Advanced Drug Delivery Reviews
Abstract: Acute wound healing is an orderly process of four overlapping events: haemostasis, inflammation, proliferation and remodelling. A drug delivery system with a temporal control of release could promote each of these events sequentially. However, acute wound healing normally proceeds very well in healthy individuals and there is little need to promote it. In the elderly and diabetics however, healing is often slow and wounds can become chronic and we need to promote their healing. Targeting the events of acute wound healing would not be appropriate for a chronic wound, which have stalled in the proinflammatory phase. They also have many additional problems such as poor circulation, low oxygen, high levels of leukocytes, high reactive oxygen species, high levels of proteolytic enzymes, high levels of proinflammatory cytokines, bacterial infection and high pH. The future challenge will be to tackle each of these negative factors to create a wound environment conducive to healing.
ISSN: 0169-409X
DOI: 10.1016/j.addr.2019.03.006
Rights: © 2019 Elsevier B.V. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:IGS Journal Articles
LKCMedicine Journal Articles
SCBE Journal Articles

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