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Title: Pituitary stem cells produce paracrine WNT signals to control the expansion of their descendant progenitor cells
Authors: Russell, John P.
Lim, Xinhong
Santambrogio, Alice
Yianni, Val
Kemkem, Yasmine
Wang, Bruce
Fish, Matthew
Haston, Scott
Grabek, Anaëlle
Hallang, Shirleen
Lodge, Emily J.
Patist, Amanda L.
Schedl, Andreas
Mollard, Patrice
Nusse, Roel
Andoniadou, Cynthia L.
Keywords: Science::Medicine
Issue Date: 2021
Source: Russell, J. P., Lim, X., Santambrogio, A., Yianni, V., Kemkem, Y., Wang, B., Fish, M., Haston, S., Grabek, A., Hallang, S., Lodge, E. J., Patist, A. L., Schedl, A., Mollard, P., Nusse, R. & Andoniadou, C. L. (2021). Pituitary stem cells produce paracrine WNT signals to control the expansion of their descendant progenitor cells. ELife, 10.
Journal: eLife
Abstract: In response to physiological demand, the pituitary gland generates new hormone-secreting cells from committed progenitor cells throughout life. It remains unclear to what extent pituitary stem cells (PSCs), which uniquely express SOX2, contribute to pituitary growth and renewal. Moreover, neither the signals that drive proliferation nor their sources have been elucidated. We have used genetic approaches in the mouse, showing that the WNT pathway is essential for proliferation of all lineages in the gland. We reveal that SOX2+ stem cells are a key source of WNT ligands. By blocking secretion of WNTs from SOX2+ PSCs in vivo, we demonstrate that proliferation of neighbouring committed progenitor cells declines, demonstrating that progenitor multiplication depends on the paracrine WNT secretion from SOX2+ PSCs. Our results indicate that stem cells can hold additional roles in tissue expansion and homeostasis, acting as paracrine signalling centres to coordinate the proliferation of neighbouring cells.
ISSN: 2050-084X
DOI: 10.7554/eLife.59142
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Organisations: Skin Research Institute of Singapore, A*STAR
Rights: © 2021 The Authors(s). This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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