Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/146986
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dc.contributor.authorZhang, Fanen_US
dc.contributor.authorLi, Fengen_US
dc.contributor.authorLu, Gui-Hongen_US
dc.contributor.authorNie, Weidongen_US
dc.contributor.authorZhang, Lijunen_US
dc.contributor.authorLv, Yanlinen_US
dc.contributor.authorBao, Weieren_US
dc.contributor.authorGao, Xiaoyongen_US
dc.contributor.authorWei, Weien_US
dc.contributor.authorPu, Kanyien_US
dc.contributor.authorXie, Hai-Yanen_US
dc.date.accessioned2021-03-16T07:25:43Z-
dc.date.available2021-03-16T07:25:43Z-
dc.date.issued2019-
dc.identifier.citationZhang, F., Li, F., Lu, G., Nie, W., Zhang, L., Lv, Y., Bao, W., Gao, X., Wei, W., Pu, K. & Xie, H. (2019). Engineering magnetosomes for ferroptosis/immunomodulation synergism in cancer. ACS Nano, 13(5), 5662-5673. https://dx.doi.org/10.1021/acsnano.9b00892en_US
dc.identifier.issn1936-0851en_US
dc.identifier.other0000-0002-6244-3187-
dc.identifier.other0000-0002-8064-6009-
dc.identifier.other0000-0002-6330-7929-
dc.identifier.urihttps://hdl.handle.net/10356/146986-
dc.description.abstractAs traditional anticancer treatments fail to significantly improve the prognoses, exploration of therapeutic modalities is urgently needed. Herein, a biomimetic magnetosome is constructed to favor the ferroptosis/immunomodulation synergism in cancer. This magnetosome is composed of an Fe3O4 magnetic nanocluster (NC) as the core and pre-engineered leukocyte membranes as the cloak, wherein TGF-β inhibitor (Ti) can be loaded inside the membrane and PD-1 antibody (Pa) can be anchored on the membrane surface. After intravenous injection, the membrane camouflage results in long circulation, and the NC core with magnetization and superparamagnetism enables magnetic targeting with magnetic resonance imaging (MRI) guidance. Once inside the tumor, Pa and Ti cooperate to create an immunogenic microenvironment, which increases the amount of H2O2 in polarized M1 macrophages and thus promotes the Fenton reaction with Fe ions released from NCs. The generated hydroxyl radicals (•OH) subsequently induce lethal ferroptosis to tumor cells, and the exposed tumor antigen, in turn, improves the microenvironment immunogenicity. The synergism of immunomodulation and ferroptosis in such a cyclical manner therefore leads to potent therapeutic effects with few abnormalities, which supports the engineered magnetosomes as a promising combination modality for anticancer therapy.en_US
dc.language.isoenen_US
dc.relation.ispartofACS Nanoen_US
dc.rights© 2019 American Chemical Society. All rights reserved.en_US
dc.subjectEngineering::Chemical engineeringen_US
dc.titleEngineering magnetosomes for ferroptosis/immunomodulation synergism in canceren_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.identifier.doi10.1021/acsnano.9b00892-
dc.identifier.pmid31046234-
dc.identifier.scopus2-s2.0-85065796466-
dc.identifier.issue5en_US
dc.identifier.volume13en_US
dc.identifier.spage5662en_US
dc.identifier.epage5673en_US
dc.subject.keywordsBiomimetic Magnetosomesen_US
dc.subject.keywordsPD-1 Antibodyen_US
dc.description.acknowledgementThis work was supported by the National Natural Science Foundation of China (Nos. 81571813, 21874011, and 21622608) and National Key R&D Program of China (2017YFA0207900).en_US
item.fulltextNo Fulltext-
item.grantfulltextnone-
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