Please use this identifier to cite or link to this item:
Title: Prevalence of normal weight obesity and its associated cardio-metabolic risk factors - results from the baseline data of the Kerala Diabetes Prevention Program (KDPP)
Authors: Kapoor, Nitin
Lotfaliany, Mojtaba
Sathish, Thirunavukkarasu
Thankappan, Kavumpurathu R.
Thomas, Nihal
Furler, John
Oldenburg, Brian
Tapp, Robyn J.
Keywords: Science::Medicine
Issue Date: 2020
Source: Kapoor, N., Lotfaliany, M., Sathish, T., Thankappan, K. R., Thomas, N., Furler, J., Oldenburg, B. & Tapp, R. J. (2020). Prevalence of normal weight obesity and its associated cardio-metabolic risk factors - results from the baseline data of the Kerala Diabetes Prevention Program (KDPP). PloS One, 15(8).
Journal: PloS One 
Abstract: Background: Cardiometabolic disorders are frequently observed among those who have obesity as measured by body mass index (BMI). However, there is limited data available on the cardiometabolic profile of those who are non-obese by BMI but with a high body fat percentage (BFP), a phenotype frequently observed in the Indian population. We examined the prevalence of individuals with normal weight obesity (NWO) and the cardiometabolic profile of NWO individuals at high risk for type 2 diabetes(T2D) in a south Asian population. Material and methods: In the Kerala Diabetes Prevention Program, individuals aged between 30 to 60 years were screened using the Indian Diabetes Risk Score(IDRS) in 60 rural communities in the Indian state of Kerala. We used data from the baseline survey of this trial for this analysis which included 1147 eligible high diabetes risk individuals(IDRS >60). NWO was defined as BMI within the normal range and a high BFP (as per Asia-pacific ethnicity based cut-off); Non-obese (NO) as normal BMI and BFP and overtly obese (OB) as BMI ≥25 kg/m2 irrespective of the BFP. Data on demographic, clinical and biochemical characteristics were collected using standardized questionnaires and protocols. Body fat percentage was assessed using TANITA body composition analyser (model SC330), based on bioelectrical impedance. Results: The mean age of participants was 47.3 ± 7.5 years and 46% were women. The proportion with NWO was 32% (n = 364; 95% CI: 29.1 to 34.5%), NO was 17% (n = 200) and OB was 51% (n = 583). Among those with NWO, 19.7% had T2D, compared to 18.7% of those who were OB (p value = 0.45) and 8% with NO (p value = 0.003). Among those with NWO, mean systolic and diastolic blood pressure were 129 ± 20; 78 ± 12 mmHg, compared to 127 ± 17; 78±11 mmHg among those with OB (p value = 0.12;0.94) and 120 ± 16; 71±10 mmHg among with NO (p value<0.001; 0.001), respectively. A similar pattern of association was observed for LDL cholesterol and triglycerides. After adjusting for other risk factors, the odds of having diabetes (OR:2.72[95% CI:1.46–5.08]) and dyslipidemia (2.37[1.55–3.64]) was significantly more in individuals with NWO as compared to non-obese individuals. Conclusions: Almost one-third of this South Asian population, at high risk for T2D, had normal weight obesity. The significantly higher cardiometabolic risk associated with increased adiposity even in lower BMI individuals has important implications for recognition in clinical practice.
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0237974
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Research Centres: Centre for Population Health Sciences 
Rights: © 2020 The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

Files in This Item:
File Description SizeFormat 
pone.0237974.pdf395.99 kBAdobe PDFThumbnail

Citations 10

Updated on Feb 23, 2024

Web of ScienceTM
Citations 10

Updated on Oct 26, 2023

Page view(s)

Updated on Feb 23, 2024

Download(s) 50

Updated on Feb 23, 2024

Google ScholarTM




Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.