Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/147097
Title: Association analysis of PSAP variants in Parkinson's disease patients
Authors: Chao, Yin Xia
Lee, Bernett
Ng, Ebonne Yulin
Lian, Michelle Mulan
Chew, Elaine Guo Yan
Tandiono, Moses
Li, Zheng
Khor, Chiea Chuen
Kumar, Prakash
Tan, Louis C. S.
Foo, Jia Nee
Tan, Eng-King
Keywords: Science::Biological sciences::Genetics
Issue Date: 2021
Source: Chao, Y. X., Lee, B., Ng, E. Y., Lian, M. M., Chew, E. G. Y., Tandiono, M., Li, Z., Khor, C. C., Kumar, P., Tan, L. C. S., Foo, J. N. & Tan, E. (2021). Association analysis of PSAP variants in Parkinson's disease patients. Brain : a Journal of Neurology, 144(1), e9-. https://dx.doi.org/10.1093/brain/awaa358
Journal: Brain : a journal of neurology
Abstract: We read with interest the recent report by Oji and colleagues who identified three exonic mutations in the prosaposin (PSAP) gene from three families with Parkinson’s disease. In addition, a case control study involving 440 Japanese and 705 patients with sporadic Parkinson’s disease from Taiwan demonstrated that that intronic variants (rs4747203 and rs885828) located in the PSAP saposin D domain increased the risk of Parkinson’s disease (Oji et al., 2020). Since the sample size for the association study was relatively small, and independent replication is a litmus test for the reproducibility of the findings, we investigated for exome and intronic variants in a much larger sample size in our Asian population.
URI: https://hdl.handle.net/10356/147097
ISSN: 0006-8950
DOI: 10.1093/brain/awaa358
Rights: © 2021 The Author(s). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. This paper was published in Brain : a journal of neurology and is made available with permission of The Author(s). Published by Oxford University Press on behalf of the Guarantors of Brain.
Fulltext Permission: embargo_20220131
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

Files in This Item:
File Description SizeFormat 
Association analysis of PSAP variants in Parkinson's disease patients.pdf
  Until 2022-01-31
219.21 kBAdobe PDFUnder embargo until Jan 31, 2022

Page view(s)

155
Updated on Dec 5, 2021

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.