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dc.contributor.authorChao, Yin Xiaen_US
dc.contributor.authorLee, Bernetten_US
dc.contributor.authorNg, Ebonne Yulinen_US
dc.contributor.authorLian, Michelle Mulanen_US
dc.contributor.authorChew, Elaine Guo Yanen_US
dc.contributor.authorTandiono, Mosesen_US
dc.contributor.authorLi, Zhengen_US
dc.contributor.authorKhor, Chiea Chuenen_US
dc.contributor.authorKumar, Prakashen_US
dc.contributor.authorTan, Louis C. S.en_US
dc.contributor.authorFoo, Jia Neeen_US
dc.contributor.authorTan, Eng-Kingen_US
dc.identifier.citationChao, Y. X., Lee, B., Ng, E. Y., Lian, M. M., Chew, E. G. Y., Tandiono, M., Li, Z., Khor, C. C., Kumar, P., Tan, L. C. S., Foo, J. N. & Tan, E. (2021). Association analysis of PSAP variants in Parkinson's disease patients. Brain : a Journal of Neurology, 144(1), e9-.
dc.description.abstractWe read with interest the recent report by Oji and colleagues who identified three exonic mutations in the prosaposin (PSAP) gene from three families with Parkinson’s disease. In addition, a case control study involving 440 Japanese and 705 patients with sporadic Parkinson’s disease from Taiwan demonstrated that that intronic variants (rs4747203 and rs885828) located in the PSAP saposin D domain increased the risk of Parkinson’s disease (Oji et al., 2020). Since the sample size for the association study was relatively small, and independent replication is a litmus test for the reproducibility of the findings, we investigated for exome and intronic variants in a much larger sample size in our Asian population.en_US
dc.description.sponsorshipNational Medical Research Council (NMRC)en_US
dc.description.sponsorshipNational Research Foundation (NRF)en_US
dc.relation.ispartofBrain : a journal of neurologyen_US
dc.rights© 2021 The Author(s). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. This paper was published in Brain : a journal of neurology and is made available with permission of The Author(s). Published by Oxford University Press on behalf of the Guarantors of Brain.en_US
dc.subjectScience::Biological sciences::Geneticsen_US
dc.titleAssociation analysis of PSAP variants in Parkinson's disease patientsen_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.contributor.researchA*STAR Institute of Material Research and Engineeringen_US
dc.description.versionAccepted versionen_US
dc.subject.keywordsParkinson's Diseaseen_US
dc.description.acknowledgementThe authors thank the National Medical Research Council (STAR award and Parkinson's disease Large Collaborative Grant MOH-OFLCG-002) and National Research Foundation (NRF fellowship: NRF-NRFF2016-03) for their support.en_US
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