Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/147097
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dc.contributor.authorChao, Yin Xiaen_US
dc.contributor.authorLee, Bernetten_US
dc.contributor.authorNg, Ebonne Yulinen_US
dc.contributor.authorLian, Michelle Mulanen_US
dc.contributor.authorChew, Elaine Guo Yanen_US
dc.contributor.authorTandiono, Mosesen_US
dc.contributor.authorLi, Zhengen_US
dc.contributor.authorKhor, Chiea Chuenen_US
dc.contributor.authorKumar, Prakashen_US
dc.contributor.authorTan, Louis C. S.en_US
dc.contributor.authorFoo, Jia Neeen_US
dc.contributor.authorTan, Eng-Kingen_US
dc.date.accessioned2021-03-23T02:42:59Z-
dc.date.available2021-03-23T02:42:59Z-
dc.date.issued2021-
dc.identifier.citationChao, Y. X., Lee, B., Ng, E. Y., Lian, M. M., Chew, E. G. Y., Tandiono, M., Li, Z., Khor, C. C., Kumar, P., Tan, L. C. S., Foo, J. N. & Tan, E. (2021). Association analysis of PSAP variants in Parkinson's disease patients. Brain : a Journal of Neurology, 144(1), e9-. https://dx.doi.org/10.1093/brain/awaa358en_US
dc.identifier.issn0006-8950en_US
dc.identifier.urihttps://hdl.handle.net/10356/147097-
dc.description.abstractWe read with interest the recent report by Oji and colleagues who identified three exonic mutations in the prosaposin (PSAP) gene from three families with Parkinson’s disease. In addition, a case control study involving 440 Japanese and 705 patients with sporadic Parkinson’s disease from Taiwan demonstrated that that intronic variants (rs4747203 and rs885828) located in the PSAP saposin D domain increased the risk of Parkinson’s disease (Oji et al., 2020). Since the sample size for the association study was relatively small, and independent replication is a litmus test for the reproducibility of the findings, we investigated for exome and intronic variants in a much larger sample size in our Asian population.en_US
dc.description.sponsorshipNational Medical Research Council (NMRC)en_US
dc.description.sponsorshipNational Research Foundation (NRF)en_US
dc.language.isoenen_US
dc.relation.ispartofBrain : a journal of neurologyen_US
dc.rights© 2021 The Author(s). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. This paper was published in Brain : a journal of neurology and is made available with permission of The Author(s). Published by Oxford University Press on behalf of the Guarantors of Brain.en_US
dc.subjectScience::Biological sciences::Geneticsen_US
dc.titleAssociation analysis of PSAP variants in Parkinson's disease patientsen_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.contributor.researchA*STAR Institute of Material Research and Engineeringen_US
dc.identifier.doi10.1093/brain/awaa358-
dc.description.versionAccepted versionen_US
dc.identifier.pmid33221828-
dc.identifier.issue1en_US
dc.identifier.volume144en_US
dc.identifier.spagee9en_US
dc.subject.keywordsParkinson's Diseaseen_US
dc.subject.keywordsGeneticsen_US
dc.description.acknowledgementThe authors thank the National Medical Research Council (STAR award and Parkinson's disease Large Collaborative Grant MOH-OFLCG-002) and National Research Foundation (NRF fellowship: NRF-NRFF2016-03) for their support.en_US
item.fulltextWith Fulltext-
item.grantfulltextembargo_20220131-
Appears in Collections:LKCMedicine Journal Articles
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