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Title: Fluorescent, prussian blue-based biocompatible nanoparticle system for multimodal imaging contrast
Authors: Forgách, László
Hegedűs, Nikolett
Horváth, Ildikó
Kiss, Bálint
Kovács, Noémi
Varga, Zoltán
Jakab, Géza
Kovács, Tibor
Padmanabhan, Parasuraman
Szigeti, Krisztián
Máthé, Domokos
Keywords: Science::Medicine
Issue Date: 2020
Source: Forgách, L., Hegedűs, N., Horváth, I., Kiss, B., Kovács, N., Varga, Z., Jakab, G., Kovács, T., Padmanabhan, P., Szigeti, K. & Máthé, D. (2020). Fluorescent, prussian blue-based biocompatible nanoparticle system for multimodal imaging contrast. Nanomaterials, 10(9).
Journal: Nanomaterials
Abstract: (1) Background: The main goal of this work was to develop a fluorescent dye-labelling technique for our previously described nanosized platform, citrate-coated Prussian blue (PB) nanoparticles (PBNPs). In addition, characteristics and stability of the PB nanoparticles labelled with fluorescent dyes were determined. (2) Methods: We adsorbed the fluorescent dyes Eosin Y and Rhodamine B and methylene blue (MB) to PB-nanoparticle systems. The physicochemical properties of these fluorescent dye-labeled PBNPs (iron(II); iron(III); octadecacyanide) were determined using atomic force microscopy, dynamic light scattering, zeta potential measurements, scanning- and transmission electron microscopy, X-ray diffraction, and Fourier-transformation infrared spectroscopy. A methylene-blue (MB) labelled, polyethylene-glycol stabilized PBNP platform was selected for further assessment of in vivo distribution and fluorescent imaging after intravenous administration in mice. (3) Results: The MB-labelled particles emitted a strong fluorescent signal at 662 nm. We found that the fluorescent light emission and steric stabilization made this PBNP-MB particle platform applicable for in vivo optical imaging. (4) Conclusion: We successfully produced a fluorescent and stable, Prussian blue-based nanosystem. The particles can be used as a platform for imaging contrast enhancement. In vivo stability and biodistribution studies revealed new aspects of the use of PBNPs.
ISSN: 2079-4991
DOI: 10.3390/nano10091732
Rights: © 2020 The Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
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