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|Title:||Fluorescent, prussian blue-based biocompatible nanoparticle system for multimodal imaging contrast||Authors:||Forgách, László
|Keywords:||Science::Medicine||Issue Date:||2020||Source:||Forgách, L., Hegedűs, N., Horváth, I., Kiss, B., Kovács, N., Varga, Z., Jakab, G., Kovács, T., Padmanabhan, P., Szigeti, K. & Máthé, D. (2020). Fluorescent, prussian blue-based biocompatible nanoparticle system for multimodal imaging contrast. Nanomaterials, 10(9). https://dx.doi.org/10.3390/nano10091732||Journal:||Nanomaterials||Abstract:||(1) Background: The main goal of this work was to develop a fluorescent dye-labelling technique for our previously described nanosized platform, citrate-coated Prussian blue (PB) nanoparticles (PBNPs). In addition, characteristics and stability of the PB nanoparticles labelled with fluorescent dyes were determined. (2) Methods: We adsorbed the fluorescent dyes Eosin Y and Rhodamine B and methylene blue (MB) to PB-nanoparticle systems. The physicochemical properties of these fluorescent dye-labeled PBNPs (iron(II); iron(III); octadecacyanide) were determined using atomic force microscopy, dynamic light scattering, zeta potential measurements, scanning- and transmission electron microscopy, X-ray diffraction, and Fourier-transformation infrared spectroscopy. A methylene-blue (MB) labelled, polyethylene-glycol stabilized PBNP platform was selected for further assessment of in vivo distribution and fluorescent imaging after intravenous administration in mice. (3) Results: The MB-labelled particles emitted a strong fluorescent signal at 662 nm. We found that the fluorescent light emission and steric stabilization made this PBNP-MB particle platform applicable for in vivo optical imaging. (4) Conclusion: We successfully produced a fluorescent and stable, Prussian blue-based nanosystem. The particles can be used as a platform for imaging contrast enhancement. In vivo stability and biodistribution studies revealed new aspects of the use of PBNPs.||URI:||https://hdl.handle.net/10356/147112||ISSN:||2079-4991||DOI:||10.3390/nano10091732||Rights:||© 2020 The Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
|Appears in Collections:||LKCMedicine Journal Articles|
Updated on Jun 30, 2022
Updated on Jun 30, 2022
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