Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/147124
Title: Mechanical tolerance of cascade bioreactions via adaptive curvature engineering for epidermal bioelectronics
Authors: Wang, Ting
Lei, Qun-Li
Wang, Ming
Deng, Guoying
Yang, Le
Liu, Xijian
Li, Chunlin
Wang, Qi
Liu, Zhihua
Wang, Jianwu
Cui, Zequn
Kevin Goldio Utama
Ni, Ran
Chen, Xiaodong
Keywords: Science::Chemistry::Analytical chemistry
Issue Date: 2020
Source: Wang, T., Lei, Q., Wang, M., Deng, G., Yang, L., Liu, X., Li, C., Wang, Q., Liu, Z., Wang, J., Cui, Z., Kevin Goldio Utama, Ni, R. & Chen, X. (2020). Mechanical tolerance of cascade bioreactions via adaptive curvature engineering for epidermal bioelectronics. Advanced Materials, 32(22), 2000991-. https://dx.doi.org/10.1002/adma.202000991
Journal: Advanced Materials 
Abstract: Epidermal bioelectronics that can monitor human health status noninvasively and in real time are core to wearable healthcare equipment. Achieving mechanically tolerant surface bioreactions that convert biochemical information to detectable signals is crucial for obtaining high sensing fidelity. In this work, by combining simulations and experiments, a typical epidermal biosensor system is investigated based on a redox enzyme cascade reaction (RECR) comprising glucose oxidase/lactate oxidase enzymes and Prussian blue nanoparticles. Simulations reveal that strain-induced change in surface reactant flux is the key to the performance drop in traditional flat bioelectrodes. In contrast, wavy bioelectrodes capable of curvature adaptation maintain the reactant flux under strain, which preserves sensing fidelity. This rationale is experimentally proven by bioelectrodes with flat/wavy geometry under both static strain and dynamic stretching. When exposed to 50% strain, the signal fluctuations for wavy bioelectrodes are only 7.0% (4.9%) in detecting glucose (lactate), which are significantly lower than the 40.3% (51.8%) in flat bioelectrodes. Based on this wavy bioelectrode, a stable human epidermal metabolite biosensor insensitive to human gestures is further demonstrated. This mechanically tolerant biosensor based on adaptive curvature engineering provides a reliable bio/chemical-information monitoring platform for soft healthcare bioelectronics.
URI: https://hdl.handle.net/10356/147124
ISSN: 1521-4095
DOI: 10.1002/adma.202000991
Rights: This is the peer reviewed version of the following article: Wang, T., Lei, Q., Wang, M., Deng, G., Yang, L., Liu, X., Li, C., Wang, Q., Liu, Z., Wang, J., Cui, Z., Kevin Goldio Utama, Ni, R. & Chen, X. (2020). Mechanical tolerance of cascade bioreactions via adaptive curvature engineering for epidermal bioelectronics. Advanced Materials, 32(22), 2000991-. https://dx.doi.org/10.1002/adma.202000991, which has been published in final form at https://doi.org/10.1002/adma.202000991. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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