Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/147164
Title: Structural regulation of myocytes in engineered healthy and diseased cardiac models
Authors: Yu, Jing
Cai, Pingqiang
Chen, Xiaodong
Keywords: Science::Medicine::Biomedical engineering
Issue Date: 2021
Source: Yu, J., Cai, P. & Chen, X. (2021). Structural regulation of myocytes in engineered healthy and diseased cardiac models. ACS Applied Bio Materials, 4(1), 267-276. https://dx.doi.org/10.1021/acsabm.0c01270
Journal: ACS Applied Bio Materials 
Abstract: The development of cardiac models that faithfully recapitulate heart conditions is the goal of cardiac biomedical research. Among the numerous limitations of current models, replication of the cardiac microenvironment is one of the key challenges, and the effect of mechanical cues remains obscure in cardiac tissue. In this paper, different topological structures in the engineered cardiac models are summarized, and mechanical regulation of myocyte morphology and functional responses are discussed. Microenvironmental cues in vivo are influencing cardiac functions from cellular to tissue levels, and replications of these micro and macro features in the in vitro cardiac model shed light on cardiac research from a mechanistic point of view. With simple manipulation of topology, both physiological and pathological cardiac constructs can be remodeled to investigate the origin of abnormal cell phenotypes and functional responses in cardiac diseases. The integration of topological guidance with heart-on-a-chip devices is covered briefly and limitations of the current cardiac constructs are also addressed for future advancements in personalized medicine.
URI: https://hdl.handle.net/10356/147164
ISSN: 2576-6422
DOI: 10.1021/acsabm.0c01270
Schools: School of Materials Science and Engineering 
Research Centres: Innovative Centre for Flexible Devices 
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Bio Materials, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsabm.0c01270
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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