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Title: Biodistribution and acute toxicity of cadmium-free quantum dots with different surface functional groups in mice following intratracheal inhalation
Authors: Lin, Guimiao
Chen, Ting
Pan, Yongning
Yang, Zhiwen
Li, Li
Yong, Ken-Tye
Wang, Xiaomei
Wang, Jie
Chen, Yajing
Jiang, Wenxiao
Weng, Shuting
Huang, Xiaorui
Kuang, Jiajie
Xu, Gaixia
Keywords: Engineering::Nanotechnology
Issue Date: 2020
Source: Lin, G., Chen, T., Pan, Y., Yang, Z., Li, L., Yong, K., Wang, X., Wang, J., Chen, Y., Jiang, W., Weng, S., Huang, X., Kuang, J. & Xu, G. (2020). Biodistribution and acute toxicity of cadmium-free quantum dots with different surface functional groups in mice following intratracheal inhalation. Nanotheranostics, 4(3), 173-183.
Journal: Nanotheranostics 
Abstract: Indium phosphide/zinc sulfate (InP/ZnS) quantum dots (QDs) are presumed to be less hazardous than those that contain cadmium. However, the toxicological profile has not been established. The present study investigated the acute toxicity of InP/ZnS QDs with different surface modifications (COOH, NH2, and OH) in mice after pulmonary aerosol inhalation. InP/ZnS QDs were able to pass through the blood-gas barrier and enter the circulation, and subsequently accumulated in major organs. No obvious changes were observed in the body weight or major organ coefficients. Red blood cell counts and platelet-related indicators were in the normal range, but the proportion of white blood cells was altered. The InP/ZnS QDs caused varying degrees of changes in some serum markers, but no histopathological abnormalities related to InP/ZnS QDs treatment was observed in major organs except that hyperemia in alveolar septa was found in lung sections. These results suggested that the effects of respiratory exposure to InP/ZnS QDs on the lungs need to be fully considered in future biomedical application although the overall toxicity of quantum dots is relatively low.
ISSN: 2206-7418
DOI: 10.7150/ntno.42786
Rights: © 2020 The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License ( See for full terms and conditions.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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