Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/147424
Title: Reduction-responsive double hydrophilic block copolymer nano-capsule synthesized via RCMP-PISA
Authors: Sarkar, Jit
Chan, Jonathan Kai Bin
Goto, Atsushi
Keywords: Science::Chemistry::Organic chemistry::Polymers
Issue Date: 2021
Source: Sarkar, J., Chan, J. K. B. & Goto, A. (2021). Reduction-responsive double hydrophilic block copolymer nano-capsule synthesized via RCMP-PISA. Polymer Chemistry, 12(7), 1060-1067. https://dx.doi.org/10.1039/d0py01764g
Journal: Polymer Chemistry
Abstract: A double hydrophilic block copolymer (DHBC) vesicle was synthesized via an organocatalyzed living radical polymerization, i.e., reversible complexation mediated polymerization (RCMP). RCMP was combined with polymerization-induced self-assembly (PISA) to give an amphiphilic block copolymer vesicle comprising hydrophilic poly(poly(ethylene glycol) methyl ether methacrylate) (PPEGMA) and hydrophobic poly(solketal methacrylate) (PSKM). With the incorporation of a crosslinker, i.e., bis(2-methacryloyl)oxyethyl disulfide (BMOD), in the vesicle, and upon the subsequent hydrolysis of the hydrophobic PSKM into hydrophilic poly(glycerol methacrylate) (PGLMA), a stable DHBC vesicle was generated. The vesicle was successfully utilized to encapsulate an external guest molecule. The encapsulated molecule was also released by cleaving the disulfide bond in the crosslinker (BMOD) in the presence of glutathione (in a reductive condition). The present vesicle consists of neutral (not acidic or basic) PEGMA and PGLMA segments and hence has no restriction in the pH range for its use. PPEGMA and PGLMA are also biocompatible. With these properties, the present DHBC vesicle may serve as a useful reduction-responsive container.
URI: https://hdl.handle.net/10356/147424
ISSN: 1759-9962
DOI: 10.1039/d0py01764g
Rights: © 2021 Royal Society of Chemistry. All rights reserved. This paper was published in Polymer Chemistry and is made available with permission of Royal Society of Chemistry.
Fulltext Permission: embargo_20220203
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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