Please use this identifier to cite or link to this item:
https://hdl.handle.net/10356/147424
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sarkar, Jit | en_US |
dc.contributor.author | Chan, Jonathan Kai Bin | en_US |
dc.contributor.author | Goto, Atsushi | en_US |
dc.date.accessioned | 2021-04-01T01:15:02Z | - |
dc.date.available | 2021-04-01T01:15:02Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Sarkar, J., Chan, J. K. B. & Goto, A. (2021). Reduction-responsive double hydrophilic block copolymer nano-capsule synthesized via RCMP-PISA. Polymer Chemistry, 12(7), 1060-1067. https://dx.doi.org/10.1039/d0py01764g | en_US |
dc.identifier.issn | 1759-9962 | en_US |
dc.identifier.uri | https://hdl.handle.net/10356/147424 | - |
dc.description.abstract | A double hydrophilic block copolymer (DHBC) vesicle was synthesized via an organocatalyzed living radical polymerization, i.e., reversible complexation mediated polymerization (RCMP). RCMP was combined with polymerization-induced self-assembly (PISA) to give an amphiphilic block copolymer vesicle comprising hydrophilic poly(poly(ethylene glycol) methyl ether methacrylate) (PPEGMA) and hydrophobic poly(solketal methacrylate) (PSKM). With the incorporation of a crosslinker, i.e., bis(2-methacryloyl)oxyethyl disulfide (BMOD), in the vesicle, and upon the subsequent hydrolysis of the hydrophobic PSKM into hydrophilic poly(glycerol methacrylate) (PGLMA), a stable DHBC vesicle was generated. The vesicle was successfully utilized to encapsulate an external guest molecule. The encapsulated molecule was also released by cleaving the disulfide bond in the crosslinker (BMOD) in the presence of glutathione (in a reductive condition). The present vesicle consists of neutral (not acidic or basic) PEGMA and PGLMA segments and hence has no restriction in the pH range for its use. PPEGMA and PGLMA are also biocompatible. With these properties, the present DHBC vesicle may serve as a useful reduction-responsive container. | en_US |
dc.description.sponsorship | National Research Foundation (NRF) | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Polymer Chemistry | en_US |
dc.rights | © 2021 Royal Society of Chemistry. All rights reserved. This paper was published in Polymer Chemistry and is made available with permission of Royal Society of Chemistry. | en_US |
dc.subject | Science::Chemistry::Organic chemistry::Polymers | en_US |
dc.title | Reduction-responsive double hydrophilic block copolymer nano-capsule synthesized via RCMP-PISA | en_US |
dc.type | Journal Article | en |
dc.contributor.school | School of Physical and Mathematical Sciences | en_US |
dc.identifier.doi | 10.1039/d0py01764g | - |
dc.description.version | Accepted version | en_US |
dc.identifier.scopus | 2-s2.0-85101405472 | - |
dc.identifier.issue | 7 | en_US |
dc.identifier.volume | 12 | en_US |
dc.identifier.spage | 1060 | en_US |
dc.identifier.epage | 1067 | en_US |
dc.subject.keywords | Biocompatibility | en_US |
dc.subject.keywords | Covalent Bonds | en_US |
dc.description.acknowledgement | This work was partly supported by National Research Foundation (NRF) Investigatorship in Singapore (NRF‐NRFI05‐ 2019‐0001). | en_US |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
Appears in Collections: | SPMS Journal Articles |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Manuscript (reposit).pdf | 984.17 kB | Adobe PDF | View/Open |
SCOPUSTM
Citations
20
13
Updated on Mar 25, 2024
Web of ScienceTM
Citations
20
10
Updated on Oct 27, 2023
Page view(s)
213
Updated on Mar 28, 2024
Download(s) 50
58
Updated on Mar 28, 2024
Google ScholarTM
Check
Altmetric
Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.