Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/147424
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dc.contributor.authorSarkar, Jiten_US
dc.contributor.authorChan, Jonathan Kai Binen_US
dc.contributor.authorGoto, Atsushien_US
dc.date.accessioned2021-04-01T01:15:02Z-
dc.date.available2021-04-01T01:15:02Z-
dc.date.issued2021-
dc.identifier.citationSarkar, J., Chan, J. K. B. & Goto, A. (2021). Reduction-responsive double hydrophilic block copolymer nano-capsule synthesized via RCMP-PISA. Polymer Chemistry, 12(7), 1060-1067. https://dx.doi.org/10.1039/d0py01764gen_US
dc.identifier.issn1759-9962en_US
dc.identifier.urihttps://hdl.handle.net/10356/147424-
dc.description.abstractA double hydrophilic block copolymer (DHBC) vesicle was synthesized via an organocatalyzed living radical polymerization, i.e., reversible complexation mediated polymerization (RCMP). RCMP was combined with polymerization-induced self-assembly (PISA) to give an amphiphilic block copolymer vesicle comprising hydrophilic poly(poly(ethylene glycol) methyl ether methacrylate) (PPEGMA) and hydrophobic poly(solketal methacrylate) (PSKM). With the incorporation of a crosslinker, i.e., bis(2-methacryloyl)oxyethyl disulfide (BMOD), in the vesicle, and upon the subsequent hydrolysis of the hydrophobic PSKM into hydrophilic poly(glycerol methacrylate) (PGLMA), a stable DHBC vesicle was generated. The vesicle was successfully utilized to encapsulate an external guest molecule. The encapsulated molecule was also released by cleaving the disulfide bond in the crosslinker (BMOD) in the presence of glutathione (in a reductive condition). The present vesicle consists of neutral (not acidic or basic) PEGMA and PGLMA segments and hence has no restriction in the pH range for its use. PPEGMA and PGLMA are also biocompatible. With these properties, the present DHBC vesicle may serve as a useful reduction-responsive container.en_US
dc.description.sponsorshipNational Research Foundation (NRF)en_US
dc.language.isoenen_US
dc.relation.ispartofPolymer Chemistryen_US
dc.rights© 2021 Royal Society of Chemistry. All rights reserved. This paper was published in Polymer Chemistry and is made available with permission of Royal Society of Chemistry.en_US
dc.subjectScience::Chemistry::Organic chemistry::Polymersen_US
dc.titleReduction-responsive double hydrophilic block copolymer nano-capsule synthesized via RCMP-PISAen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.identifier.doi10.1039/d0py01764g-
dc.description.versionAccepted versionen_US
dc.identifier.scopus2-s2.0-85101405472-
dc.identifier.issue7en_US
dc.identifier.volume12en_US
dc.identifier.spage1060en_US
dc.identifier.epage1067en_US
dc.subject.keywordsBiocompatibilityen_US
dc.subject.keywordsCovalent Bondsen_US
dc.description.acknowledgementThis work was partly supported by National Research Foundation (NRF) Investigatorship in Singapore (NRF‐NRFI05‐ 2019‐0001).en_US
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