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dc.contributor.authorChew, S. C.en_US
dc.contributor.authorKundukad, Binuen_US
dc.contributor.authorTeh, Wooi Keongen_US
dc.contributor.authorDoyle, Patricken_US
dc.contributor.authorYang, L.en_US
dc.contributor.authorRice, Scott A.en_US
dc.contributor.authorKjelleberg, Staffanen_US
dc.date.accessioned2021-04-08T02:52:36Z-
dc.date.available2021-04-08T02:52:36Z-
dc.date.issued2016-
dc.identifier.citationChew, S. C., Kundukad, B., Teh, W. K., Doyle, P., Yang, L., Rice, S. A. & Kjelleberg, S. (2016). Mechanical signatures of microbial biofilms in micropillar-embedded growth chambers. Soft Matter, 12(23), 5224-5232. https://dx.doi.org/10.1039/c5sm02755aen_US
dc.identifier.issn1744-6848en_US
dc.identifier.urihttps://hdl.handle.net/10356/147518-
dc.description.abstractBiofilms are surface-attached communities of microorganisms embedded in an extracellular matrix and are essential for the cycling of organic matter in natural and engineered environments. They are also the leading cause of many infections, for example, those associated with chronic wounds and implanted medical devices. The extracellular matrix is a key biofilm component that determines its architecture and defines its physical properties. Herein, we used growth chambers embedded with micropillars to study the net mechanical forces (differential pressure) exerted during biofilm formation in situ. Pressure from the biofilm is transferred to the micropillars via the extracellular matrix, and reduction of major matrix components decreases the magnitude of micropillar deflections. The spatial arrangement of micropillar deflections caused by pressure differences in the different biofilm strains may potentially be used as mechanical signatures for biofilm characterization. Hence, we submit that micropillar-embedded growth chambers provide insights into the mechanical properties and dynamics of the biofilm and its matrix.en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.description.sponsorshipNational Research Foundation (NRF)en_US
dc.language.isoenen_US
dc.relation.ispartofSoft Matteren_US
dc.rights© 2016 The Royal Society of Chemistry. This article is licensed under a Creative Commons Attirbution-NonCommercial 3.0 Unported Licence.en_US
dc.subjectScience::Biological sciencesen_US
dc.titleMechanical signatures of microbial biofilms in micropillar-embedded growth chambersen_US
dc.typeJournal Articleen
dc.contributor.schoolInterdisciplinary Graduate School (IGS)en_US
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.contributor.researchSingapore Centre for Environmental Life Sciences and Engineeringen_US
dc.identifier.doi10.1039/c5sm02755a-
dc.description.versionPublished versionen_US
dc.identifier.pmid12-
dc.identifier.scopus2-s2.0-84973902146-
dc.identifier.issue23en_US
dc.identifier.volume12en_US
dc.identifier.spage5224en_US
dc.identifier.epage5232en_US
dc.subject.keywordsBiofilmen_US
dc.subject.keywordsBacteriumen_US
dc.description.acknowledgementWe acknowledge financial support from the Singapore Centre for Environmental Life Sciences Engineering (SCELSE), whose research is funded by the National Research Foundation Singapore, Ministry of Education Singapore, Nanyang Technological University and National University of Singapore, under its Research Centre of Excellence program. We also acknowledge Singapore MIT Alliance for Research and Technology’s research program in BioSystems and Micromechanics supported by the National Research Foundation Singapore.en_US
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