Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/147531
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dc.contributor.authorZan, Pingen_US
dc.contributor.authorThan, Aungen_US
dc.contributor.authorDuong, Phan Khanhen_US
dc.contributor.authorSong, Juhaen_US
dc.contributor.authorXu, Chuanhuien_US
dc.contributor.authorChen, Pengen_US
dc.date.accessioned2021-04-06T07:38:23Z-
dc.date.available2021-04-06T07:38:23Z-
dc.date.issued2019-
dc.identifier.citationZan, P., Than, A., Duong, P. K., Song, J., Xu, C. & Chen, P. (2019). Antimicrobial microneedle patch for treating deep cutaneous fungal infection. Advanced Therapeutics, 2(10), 1900064-. https://dx.doi.org/10.1002/adtp.201900064en_US
dc.identifier.issn2366-3987en_US
dc.identifier.urihttps://hdl.handle.net/10356/147531-
dc.description.abstractSubcutaneous fungal infection is often difficult to be treated by the conventional topical application or oral intake of antifungal agents because of low drug bioavailability to the infection site, lack of sustained therapeutic effect, and development of drug resistance. Here, a new strategy using polymeric microneedle (MN) patches to overcome the skin barrier is reported. MN is made of a biocompatible and biodegradable chitosan–polyethylenimine copolymer, which possesses antimicrobial property immune to drug resistance and allows sustained drug release. Using a fungal infection mouse model, it is demonstrated that MN patches encapsulated with antifungal agent amphotericin B offer outstanding treatment effectiveness. It is attributable to the high bioavailability of therapeutics and synergistic actions of the antifungal polymer and drug.en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.language.isoenen_US
dc.relation.ispartofAdvanced Therapeuticsen_US
dc.relation.uri10.21979/N9/96LHKLen_US
dc.rightsThis is the peer reviewed version of the following article: Zan, P., Than, A., Duong, P. K., Song, J., Xu, C. & Chen, P. (2019). Antimicrobial microneedle patch for treating deep cutaneous fungal infection. Advanced Therapeutics, 2(10), 1900064-. https://dx.doi.org/10.1002/adtp.201900064, which has been published in final form at https://doi.org/10.1002/adtp.201900064. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en_US
dc.subjectEngineeringen_US
dc.titleAntimicrobial microneedle patch for treating deep cutaneous fungal infectionen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.contributor.researchInnovative Centre for Flexible Devicesen_US
dc.identifier.doi10.1002/adtp.201900064-
dc.identifier.issue10en_US
dc.identifier.volume2en_US
dc.identifier.spage1900064en_US
dc.subject.keywordsMicroneedlesen_US
dc.subject.keywordsFungal Infectionen_US
dc.description.acknowledgementThis research was supported by Ministry of Education - Singapore (MOE AcRF Tier 1: RG52/17).en_US
item.grantfulltextopen-
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