Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/147531
Title: Antimicrobial microneedle patch for treating deep cutaneous fungal infection
Authors: Zan, Ping
Than, Aung
Duong, Phan Khanh
Song, Juha
Xu, Chuanhui
Chen, Peng
Keywords: Engineering
Issue Date: 2019
Source: Zan, P., Than, A., Duong, P. K., Song, J., Xu, C. & Chen, P. (2019). Antimicrobial microneedle patch for treating deep cutaneous fungal infection. Advanced Therapeutics, 2(10), 1900064-. https://dx.doi.org/10.1002/adtp.201900064
Journal: Advanced Therapeutics 
Abstract: Subcutaneous fungal infection is often difficult to be treated by the conventional topical application or oral intake of antifungal agents because of low drug bioavailability to the infection site, lack of sustained therapeutic effect, and development of drug resistance. Here, a new strategy using polymeric microneedle (MN) patches to overcome the skin barrier is reported. MN is made of a biocompatible and biodegradable chitosan–polyethylenimine copolymer, which possesses antimicrobial property immune to drug resistance and allows sustained drug release. Using a fungal infection mouse model, it is demonstrated that MN patches encapsulated with antifungal agent amphotericin B offer outstanding treatment effectiveness. It is attributable to the high bioavailability of therapeutics and synergistic actions of the antifungal polymer and drug.
URI: https://hdl.handle.net/10356/147531
ISSN: 2366-3987
DOI: 10.1002/adtp.201900064
DOI (Related Dataset): 10.21979/N9/96LHKL
Schools: School of Chemical and Biomedical Engineering 
Research Centres: Innovative Centre for Flexible Devices 
Rights: This is the peer reviewed version of the following article: Zan, P., Than, A., Duong, P. K., Song, J., Xu, C. & Chen, P. (2019). Antimicrobial microneedle patch for treating deep cutaneous fungal infection. Advanced Therapeutics, 2(10), 1900064-. https://dx.doi.org/10.1002/adtp.201900064, which has been published in final form at https://doi.org/10.1002/adtp.201900064. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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