Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/147784
Title: Polycarbonate : antimicrobial polymer delivery, monomer synthesis, rapid polymerization and functionalization
Authors: Tan, Eddy Wei Ping
Keywords: Science::Chemistry::Organic chemistry::Polymers
Science::Biological sciences::Microbiology::Drug Resistance
Issue Date: 2021
Publisher: Nanyang Technological University
Source: Tan, E. W. P. (2021). Polycarbonate : antimicrobial polymer delivery, monomer synthesis, rapid polymerization and functionalization. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/147784
Abstract: Ring-opening polymerization of cyclic carbonate monomers is the most common method used to synthesize a range of polycarbonates with unique properties for various applications. This thesis will explore three different areas related to the field of polycarbonates. The first chapter will examine the therapeutic potential of coacervates formed through the complexation of positively charged guanidinium-functionalized antimicrobial polycarbonate with diblock copolymers composed of methoxy poly(ethylene glycol) and negatively charged polycarbonate. The second chapter presents two novel and simple synthetic routes to access cyclic carbonate monomers in bulk while avoiding the use of highly toxic phosgene or chloroformate reagents and tedious protection-deprotection protocols. In the final chapter, the post-polymerization routes for polycarbonate platform were expanded through the development of two new functionalization routes using para-fluoro-thiol SNAr substitution reaction.
URI: https://hdl.handle.net/10356/147784
DOI: 10.32657/10356/147784
Rights: This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
Fulltext Permission: embargo_20230412
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Theses

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  Until 2023-04-12
9.11 MBAdobe PDFUnder embargo until Apr 12, 2023

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