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Title: Genomic study of blaIMI-positive Enterobacter cloacae complex in Singapore over a five-year study period
Authors: Octavia, Sophie
Koh, Tse Hsien
Ng, Oon Tek
Marimuthu, Kalisvar
Venkatachalam, Indumathi
Lin, Raymond T. P.
Teo, Jeanette W. P.
Keywords: Science::Medicine
Issue Date: 2020
Source: Octavia, S., Koh, T. H., Ng, O. T., Marimuthu, K., Venkatachalam, I., Lin, R. T. P. & Teo, J. W. P. (2020). Genomic study of blaIMI-positive Enterobacter cloacae complex in Singapore over a five-year study period. Antimicrobial Agents and Chemotherapy, 64(8).
Project: NMRC/CIRG/1463/2016
Journal: Antimicrobial Agents and Chemotherapy
Abstract: The blaIMI gene is rarely detected outside the Enterobacter genus. Genomic characterization of 87 blaIMI-positive Enterobacter cloacae complex members revealed that the largest phylogenomic clade was made up of E. cloacae subsp. cloacae (71.3%), followed by the newly described species E. bugandensis (13.8%), E. sichuanensis (10.3%), and E. roggenkampii (4.6%). IMI-1 was the predominant carbapenemase variant (86/87, 98.9%). All the blaIMI genes were associated with chromosomally integrated Xer-dependent integrative mobile elements (IMEXs), with two new variants detected.
ISSN: 0066-4804
DOI: 10.1128/AAC.00510-20
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: © 2020 American Society for Microbiology. All Rights Reserved. This paper was published in Antimicrobial Agents and Chemotherapy and is made available with permission of American Society for Microbiology.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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