Please use this identifier to cite or link to this item:
https://hdl.handle.net/10356/147810
Title: | Genomic study of blaIMI-positive Enterobacter cloacae complex in Singapore over a five-year study period | Authors: | Octavia, Sophie Koh, Tse Hsien Ng, Oon Tek Marimuthu, Kalisvar Venkatachalam, Indumathi Lin, Raymond T. P. Teo, Jeanette W. P. |
Keywords: | Science::Medicine | Issue Date: | 2020 | Source: | Octavia, S., Koh, T. H., Ng, O. T., Marimuthu, K., Venkatachalam, I., Lin, R. T. P. & Teo, J. W. P. (2020). Genomic study of blaIMI-positive Enterobacter cloacae complex in Singapore over a five-year study period. Antimicrobial Agents and Chemotherapy, 64(8). https://dx.doi.org/10.1128/AAC.00510-20 | Project: | NMRC/CIRG/1463/2016 MOE2015-T2-2-096 NMRCCGAug16C005 NMRC/CSA-INV/0002/2016 |
Journal: | Antimicrobial Agents and Chemotherapy | Abstract: | The blaIMI gene is rarely detected outside the Enterobacter genus. Genomic characterization of 87 blaIMI-positive Enterobacter cloacae complex members revealed that the largest phylogenomic clade was made up of E. cloacae subsp. cloacae (71.3%), followed by the newly described species E. bugandensis (13.8%), E. sichuanensis (10.3%), and E. roggenkampii (4.6%). IMI-1 was the predominant carbapenemase variant (86/87, 98.9%). All the blaIMI genes were associated with chromosomally integrated Xer-dependent integrative mobile elements (IMEXs), with two new variants detected. | URI: | https://hdl.handle.net/10356/147810 | ISSN: | 0066-4804 | DOI: | 10.1128/AAC.00510-20 | Schools: | Lee Kong Chian School of Medicine (LKCMedicine) | Rights: | © 2020 American Society for Microbiology. All Rights Reserved. This paper was published in Antimicrobial Agents and Chemotherapy and is made available with permission of American Society for Microbiology. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | LKCMedicine Journal Articles |
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Antimicrobial Agents and Chemotherapy-2020-Octavia-e00510-20.full.pdf | 1.67 MB | Adobe PDF | ![]() View/Open |
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