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dc.contributor.authorLoh, Zhi Yangen_US
dc.identifier.citationLoh, Z. Y. (2020). Structural and biochemical study of Candida albicans polarisomal proteins. Doctoral thesis, Nanyang Technological University, Singapore.
dc.description.abstractThe polarisome is a multi-protein complex involved in the assembly of actin cytoskeleton during polarised hyphae growth in pathogenic yeast C. albicans. In this thesis, we present the crystal structure of C. albicans polarisomal protein Aip5 (786-896) at 2.65 Å resolution. Structural comparison of nucleation promoting factor Aip5 with its S. cerevisiae homolog revealed the difference in actin-binding loop flexibility, which may account for their differential actin-binding affinities reported in literature.en_US
dc.publisherNanyang Technological Universityen_US
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).en_US
dc.subjectScience::Biological sciences::Biochemistryen_US
dc.subjectScience::Biological sciences::Microbiologyen_US
dc.titleStructural and biochemical study of Candida albicans polarisomal proteinsen_US
dc.typeThesis-Doctor of Philosophyen_US
dc.contributor.supervisorGao Yongguien_US
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.description.degreeDoctor of Philosophyen_US
dc.contributor.researchNTU Institute of Structural Biologyen_US
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