Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/147880
Title: Structural and biochemical study of Candida albicans polarisomal proteins
Authors: Loh, Zhi Yang
Keywords: Science::Biological sciences::Biochemistry
Science::Biological sciences::Microbiology
Issue Date: 2020
Publisher: Nanyang Technological University
Source: Loh, Z. Y. (2020). Structural and biochemical study of Candida albicans polarisomal proteins. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/147880
Abstract: The polarisome is a multi-protein complex involved in the assembly of actin cytoskeleton during polarised hyphae growth in pathogenic yeast C. albicans. In this thesis, we present the crystal structure of C. albicans polarisomal protein Aip5 (786-896) at 2.65 Å resolution. Structural comparison of nucleation promoting factor Aip5 with its S. cerevisiae homolog revealed the difference in actin-binding loop flexibility, which may account for their differential actin-binding affinities reported in literature.
URI: https://hdl.handle.net/10356/147880
DOI: 10.32657/10356/147880
Rights: This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
Fulltext Permission: embargo_20260414
Fulltext Availability: With Fulltext
Appears in Collections:SBS Theses

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