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https://hdl.handle.net/10356/148217| Title: | N-heterocyclic carbene-catalyzed atroposelective annulation for access to thiazine derivatives with C-N axial chirality | Authors: | Li, Tingting Mou, Chengli Qi, Puying Peng, Xiaolin Jiang, Shichun Hao, Gefei Xue, Wei Yang, Song Hao, Lin Chi, Robin Yonggui Jin, Zhichao |
Keywords: | Science | Issue Date: | 2021 | Source: | Li, T., Mou, C., Qi, P., Peng, X., Jiang, S., Hao, G., Xue, W., Yang, S., Hao, L., Chi, R. Y. & Jin, Z. (2021). N-heterocyclic carbene-catalyzed atroposelective annulation for access to thiazine derivatives with C-N axial chirality. Angewandte Chemie International Edition, 60(17), 9362-9367. https://dx.doi.org/10.1002/anie.202010606 | Journal: | Angewandte Chemie International Edition | Abstract: | A catalytic atroposelective cycloaddition reaction between thioureas and ynals is developed. This reaction features the first NHC-catalyzed addition of thioureas to acetylenic acylazolium intermediates to eventually set up C-N axial chirality with excellent optical purities. The obtained axially chiral thiazine derivative products bear multiple functional groups and are feasible for further transformations. | URI: | https://hdl.handle.net/10356/148217 | ISSN: | 1521-3773 | DOI: | 10.1002/anie.202010606 | Schools: | School of Physical and Mathematical Sciences | Rights: | This is the peer reviewed version of the following article: Li, T., Mou, C., Qi, P., Peng, X., Jiang, S., Hao, G., Xue, W., Yang, S., Hao, L., Chi, R. Y. & Jin, Z. (2021). N-heterocyclic carbene-catalyzed atroposelective annulation for access to thiazine derivatives with C-N axial chirality. Angewandte Chemie International Edition, 60(17), 9362-9367. https://dx.doi.org/10.1002/anie.202010606, which has been published in final form at https://doi.org/10.1002/anie.202010606. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
| Appears in Collections: | SPMS Journal Articles |
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| N-heterocyclic carbene-catalyzed atroposelective annulation for access to thiazine derivatives with C-N axial chirality.pdf | 893.05 kB | Adobe PDF |  View/Open |
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