Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/148341
Title: Thermal-disrupting interface mitigates intercellular cohesion loss for accurate topical antibacterial therapy
Authors: Hu, Benhui
Berkey, Christopher
Feliciano, Timothy
Chen, Xiaohong
Li, Zhuyun
Chen, Chao
Amini, Shahrouz
Nai, Mui Hoon
Lei, Qun-Li
Ni, Ran
Wang, Juan
Leow, Wan Ru
Pan, Shaowu
Li, Yong-Qiang
Cai, Pingqiang
Miserez, Ali
Li, Shuzhou
Lim, Chwee Teck
Wu, Yun-Long
Odom, Teri W.
Dauskardt, Reinhold H.
Chen, Xiaodong
Keywords: Engineering
Issue Date: 2020
Source: Hu, B., Berkey, C., Feliciano, T., Chen, X., Li, Z., Chen, C., Amini, S., Nai, M. H., Lei, Q., Ni, R., Wang, J., Leow, W. R., Pan, S., Li, Y., Cai, P., Miserez, A., Li, S., Lim, C. T., Wu, Y., ...Chen, X. (2020). Thermal-disrupting interface mitigates intercellular cohesion loss for accurate topical antibacterial therapy. Advanced Materials, 32(12), e1907030-. https://dx.doi.org/10.1002/adma.201907030
Project: NRF-NRFI2017-07
Journal: Advanced Materials
Abstract: Bacterial infections remain a leading threat to global health because of the misuse of antibiotics and the rise in drug-resistant pathogens. Although several strategies such as photothermal therapy and magneto-thermal therapy can suppress bacterial infections, excessive heat often damages host cells and lengthens the healing time. Here, a localized thermal managing strategy, thermal-disrupting interface induced mitigation (TRIM), is reported, to minimize intercellular cohesion loss for accurate antibacterial therapy. The TRIM dressing film is composed of alternative microscale arrangement of heat-responsive hydrogel regions and mechanical support regions, which enables the surface microtopography to have a significant effect on disrupting bacterial colonization upon infrared irradiation. The regulation of the interfacial contact to the attached skin confines the produced heat and minimizes the risk of skin damage during thermoablation. Quantitative mechanobiology studies demonstrate the TRIM dressing film with a critical dimension for surface features plays a critical role in maintaining intercellular cohesion of the epidermis during photothermal therapy. Finally, endowing wound dressing with the TRIM effect via in vivo studies in S. aureus infected mice demonstrates a promising strategy for mitigating the side effects of photothermal therapy against a wide spectrum of bacterial infections, promoting future biointerface design for antibacterial therapy.
URI: https://hdl.handle.net/10356/148341
ISSN: 0935-9648
DOI: 10.1002/adma.201907030
Rights: This is the peer reviewed version of the following article: Hu, B., Berkey, C., Feliciano, T., Chen, X., Li, Z., Chen, C., Amini, S., Nai, M. H., Lei, Q., Ni, R., Wang, J., Leow, W. R., Pan, S., Li, Y., Cai, P., Miserez, A., Li, S., Lim, C. T., Wu, Y., ...Chen, X. (2020). Thermal-disrupting interface mitigates intercellular cohesion loss for accurate topical antibacterial therapy. Advanced Materials, 32(12), e1907030-. https://dx.doi.org/10.1002/adma.201907030, which has been published in final form at https://doi.org/10.1002/adma.201907030. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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