Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/148396
Title: Chemical toolbox to decode the microbiota lexicon
Authors: Qiao, Yuan
Hayashi, Hirohito
Teo, Seng Chong
Keywords: Science::Chemistry
Issue Date: 2020
Source: Qiao, Y., Hayashi, H. & Teo, S. C. (2020). Chemical toolbox to decode the microbiota lexicon. Chemistry - An Asian Journal, 15(14), 2117-2128. https://dx.doi.org/10.1002/asia.202000541
Project: NRF-NRFF12-2020-0006 
NRFF12-2020-0008 
04INS000764C230 
04MNP001939C230 
Journal: Chemistry - An Asian Journal 
Abstract: The human microbiota deploys a diverse range of molecules and metabolites to engage in chemical communications with the host, mediating fundamental aspects of host health. Studies of the structures and activities of bioactive molecules produced by the microbiota are imperative to address their implications in microbiota associated diseases in human. By drawing experiences from different research fields, chemists and chemical biologists, who are experts in dealing with chemical molecules, are uniquely positioned to contribute to the emerging knowledge of human microbiota. In this minireview, we discuss the current chemical tools and methods that are pertinent to the discovery of microbiota molecules and metabolites, characterizations of their protein targets, as well as evaluations of their biodistributions in hosts. These are key aspects in understanding the chemical underpinnings of the microbiota-host interactions that would enable future development of diagnostics and therapeutics targeting the human microbiota.
URI: https://hdl.handle.net/10356/148396
ISSN: 1861-4728
DOI: 10.1002/asia.202000541
Schools: School of Physical and Mathematical Sciences 
Rights: This is the peer reviewed version of the following article: Qiao, Y., Hayashi, H. & Teo, S. C. (2020). Chemical toolbox to decode the microbiota lexicon. Chemistry - An Asian Journal, 15(14), 2117-2128, which has been published in final form at https://doi.org/10.1002/asia.202000541. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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