Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/148595
Title: Fungi.guru : comparative genomic and transcriptomic resource for the fungi kingdom
Authors: Lim, Jolyn Jia Jia
Koh, Jace
Moo, Jia Rong
Villanueva, Erielle Marie Fajardo
Putri, Dhira Anindya
Lim, Yuen Shan
Seetoh, Wei Song
Mulupuri, Sriya
Ng, Janice Wan Zhen
Nguyen, Nhi Le Uyen
Reji, Rinta
Foo, Herman
Zhao, Margaret Xuan
Chan, Tong Ling
Rodrigues, Edbert Edric
Kairon, Ryanjit Singh
Hee, Ker Min
Chee, Natasha Cassandra
Low, Ann Don
Chen, Zoe Hui Xin
Lim, Shan Chun
Lunardi, Vanessa
Fong, Tuck Choy
Chua, Cherlyn Xin'Er
Koh, Kenny Ting Sween
Julca, Irene
Delli-Ponti, Riccardo
Ng, Jonathan Wei Xiong
Mutwil, Marek
Keywords: Science::Biological sciences
Issue Date: 2020
Source: Lim, J. J. J., Koh, J., Moo, J. R., Villanueva, E. M. F., Putri, D. A., Lim, Y. S., Seetoh, W. S., Mulupuri, S., Ng, J. W. Z., Nguyen, N. L. U., Reji, R., Foo, H., Zhao, M. X., Chan, T. L., Rodrigues, E. E., Kairon, R. S., Hee, K. M., Chee, N. C., Low, A. D., ...Mutwil, M. (2020). Fungi.guru : comparative genomic and transcriptomic resource for the fungi kingdom. Computational and Structural Biotechnology Journal, 18, 3788-3795. https://dx.doi.org/10.1016/j.csbj.2020.11.019
Project: MOE2018-T2-2-053
Journal: Computational and Structural Biotechnology Journal
Abstract: The fungi kingdom is composed of eukaryotic heterotrophs, which are responsible for balancing the ecosystem and play a major role as decomposers. They also produce a vast diversity of secondary metabolites, which have antibiotic or pharmacological properties. However, our lack of knowledge of gene function in fungi precludes us from tailoring them to our needs and tapping into their metabolic diversity. To help remedy this, we gathered genomic and gene expression data of 19 most widely-researched fungi to build an online tool, fungi.guru, which contains tools for cross-species identification of conserved pathways, functional gene modules, and gene families. We exemplify how our tool can elucidate the molecular function, biological process and cellular component of genes involved in various biological processes, by identifying a secondary metabolite pathway producing gliotoxin in Aspergillus fumigatus, the catabolic pathway of cellulose in Coprinopsis cinerea and the conserved DNA replication pathway in Fusarium graminearum and Pyricularia oryzae. The tool is available at www.fungi.guru.
URI: https://hdl.handle.net/10356/148595
ISSN: 2001-0370
DOI: 10.1016/j.csbj.2020.11.019
Rights: © 2020 The Author(s). Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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