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dc.contributor.authorPae, Jian Yien_US
dc.contributor.authorNair, Radhika V.en_US
dc.contributor.authorPadmanabhan, Parasuramanen_US
dc.contributor.authorRadhakrishnan, Gayathrien_US
dc.contributor.authorGulyás, Balázsen_US
dc.contributor.authorMatham, Murukeshan Vadakkeen_US
dc.identifier.citationPae, J. Y., Nair, R. V., Padmanabhan, P., Radhakrishnan, G., Gulyás, B. & Matham, M. V. (2021). Gold nano-urchins enhanced surface plasmon resonance (SPR) biosensors for the detection of estrogen receptor alpha (ERα). IEEE Journal of Selected Topics in Quantum Electronics, 27(5), 1-6.
dc.description.abstractBreast cancer is the deadliest form of cancer in women, but it also has very high survival rates when treated early. Existing breast cancer detection methods such as mammography are ineffective in the early detection of breast cancer due to the low uptake among women and the need for regular screening. Therefore, biosensors have been proposed as an alternative method for cost-effective breast cancer screening which may encourage more women to go for screening more regularly. In this paper, a gold nano-urchins enhanced plasmonic sensor is demonstrated for the detection of a typical breast cancer marker, estrogen receptor alpha (ER). The localized field confinement effect due to the sharp features of the nano-urchins amplifies the biosensing signal and improves its sensitivity as compared to a conventional surface plasmon resonance (SPR) biosensor.en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.description.sponsorshipNational Research Foundation (NRF)en_US
dc.relation.ispartofIEEE Journal of Selected Topics in Quantum Electronicsen_US
dc.rights© 2021 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. The published version is available at:
dc.titleGold nano-urchins enhanced surface plasmon resonance (SPR) biosensors for the detection of estrogen receptor alpha (ERα)en_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Mechanical and Aerospace Engineeringen_US
dc.description.versionAccepted versionen_US
dc.subject.keywordsBiomedical Applicationsen_US
dc.description.acknowledgementThis work was supported in part by Ministry of Education, Singapore under the Academic Research Fund Tier 1 Grant RG192/17. The work of Jian Yi Pae was supported NTU for the Research Student Scholarship and SC3DP which is supported by the National Research Foundation, Prime Minister’s Office, Singapore under its Medium-Sized Centre funding scheme. The work of Parasuraman Padmanabhan and Balázs Gulyás was supported by the Imaging Probe Development Platform (IPDP) and the support from CoNiC at NTU.en_US
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