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Title: Gold nano-urchins enhanced surface plasmon resonance (SPR) biosensors for the detection of estrogen receptor alpha (ERα)
Authors: Pae, Jian Yi
Nair, Radhika V.
Padmanabhan, Parasuraman
Radhakrishnan, Gayathri
Gulyás, Balázs
Matham, Murukeshan Vadakke
Keywords: Science
Issue Date: 2021
Source: Pae, J. Y., Nair, R. V., Padmanabhan, P., Radhakrishnan, G., Gulyás, B. & Matham, M. V. (2021). Gold nano-urchins enhanced surface plasmon resonance (SPR) biosensors for the detection of estrogen receptor alpha (ERα). IEEE Journal of Selected Topics in Quantum Electronics, 27(5), 1-6.
Journal: IEEE Journal of Selected Topics in Quantum Electronics
Abstract: Breast cancer is the deadliest form of cancer in women, but it also has very high survival rates when treated early. Existing breast cancer detection methods such as mammography are ineffective in the early detection of breast cancer due to the low uptake among women and the need for regular screening. Therefore, biosensors have been proposed as an alternative method for cost-effective breast cancer screening which may encourage more women to go for screening more regularly. In this paper, a gold nano-urchins enhanced plasmonic sensor is demonstrated for the detection of a typical breast cancer marker, estrogen receptor alpha (ER). The localized field confinement effect due to the sharp features of the nano-urchins amplifies the biosensing signal and improves its sensitivity as compared to a conventional surface plasmon resonance (SPR) biosensor.
ISSN: 1558-4542
DOI: 10.1109/JSTQE.2021.3069453
Rights: © 2021 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. The published version is available at:
Fulltext Permission: open
Fulltext Availability: With Fulltext
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