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Title: Perylene diimide oligomer nanoparticles with ultrahigh photothermal conversion efficiency for cancer theranostics
Authors: Gong, Qiuyu
Xing, Jie
Huang, Yinjuan
Wu, Aiguo
Yu, Jing
Zhang, Qichun
Keywords: Science::Chemistry::Biochemistry
Issue Date: 2020
Source: Gong, Q., Xing, J., Huang, Y., Wu, A., Yu, J. & Zhang, Q. (2020). Perylene diimide oligomer nanoparticles with ultrahigh photothermal conversion efficiency for cancer theranostics. ACS Applied Bio Materials, 3(3), 1607-1615.
Project: NRF-NRFF11-2019-0004 
Grants RG 94/18 
Grants RG 111/17, RG 2/17, RG 114/16, RG 113/18 
Grants MOE 2017-T2-1-021 
MOE 2018-T2-1- 070 
Journal: ACS Applied Bio Materials 
Abstract: Developing one agent that has reasonable stability and ultrahigh photothermal conversion efficiency (PTCE) for near-infrared (NIR) photothermal cancer treatment remains a great challenge, but is highly desirable. In this research, we developed a perylene diimide (PDI)-based oligomer (OPDI) through coupling monomeric PDI derivatives together. OPDI exhibited slightly red-shifted absorption at NIR region compared with monomeric PDI. More importantly, the self-assembled OPDI nanoparticles not only exhibited high stability and preferable biocompatibility, but also possessed an ultrahigh PTCE (up to 79.8%, higher than many other photothermal agents reported before). This OPDI photothermal agent has been demonstrated to exhibit excellent therapeutic effects. Our research provides a guide for the exploitation of photothermal agents with ultrahigh PTCE.
ISSN: 2576-6422
DOI: 10.1021/acsabm.9b01187
Schools: School of Materials Science and Engineering 
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Bio Materials, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
Fulltext Permission: open
Fulltext Availability: With Fulltext
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