Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/148642
Title: NHC-catalyzed cascade reaction between β-methyl enals and dienones for quick construction of complex multicyclic lactones
Authors: Sun, Jun
Xu, Jun
Nie, Guihua
Jin, Zhichao
Chi, Robin Yonggui
Keywords: Science::Chemistry
Issue Date: 2020
Source: Sun, J., Xu, J., Nie, G., Jin, Z. & Chi, R. Y. (2020). NHC-catalyzed cascade reaction between β-methyl enals and dienones for quick construction of complex multicyclic lactones. Organic Letters, 22(7), 2595-2599. https://dx.doi.org/10.1021/acs.orglett.0c00533
Journal: Organic Letters
Abstract: A NHC-promoted cascade reaction between β-methyl enal and dienone is developed for quick access to multicyclic lactone molecules bearing quaternary chiral carbon centers. Our study constitutes the first 1,6-addition of the acylazolium vinyl enolate γ-carbon via NHC catalysis and provides rapid access to complex lactone molecules that are otherwise difficult to prepare. The structurally sophisticated lactone products bearing up to four fused ring structures are afforded in up to quantitative yields with good to excellent enantioselectivities.
URI: https://hdl.handle.net/10356/148642
ISSN: 1523-7052
DOI: 10.1021/acs.orglett.0c00533
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.orglett.0c00533
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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