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|Title:||Distinct genetic signatures of cortical and subcortical regions associated with human memory||Authors:||Tan, Pin Kwang
|Keywords:||Social sciences::Psychology||Issue Date:||2019||Source:||Tan, P. K., Ananyev, E. & Hsieh, P. (2019). Distinct genetic signatures of cortical and subcortical regions associated with human memory. ENeuro, 6(6), ENEURO.0283-19.2019-. https://dx.doi.org/10.1523/ENEURO.0283-19.2019||Journal:||eNeuro||Abstract:||Despite the discovery of gene variants linked to memory performance, understanding the genetic basis of adult human memory remains a challenge. Here, we devised an unsupervised framework that relies on spatial correlations between human transcriptome data and functional neuroimaging maps to uncover the genetic signatures of memory in functionally-defined cortical and subcortical memory regions. Results were validated with animal literature and showed that our framework is highly effective in identifying memory-related processes and genes compared to a control cognitive function. Genes preferentially expressed in cortical memory regions are linked to memory-related processes such as immune and epigenetic regulation. Genes expressed in subcortical memory regions are associated with neurogenesis and glial cell differentiation. Genes expressed in both cortical and subcortical memory areas are involved in the regulation of transcription, synaptic plasticity, and glutamate receptor signaling. Furthermore, distinct memory-associated genes such as PRKCD and CDK5 are linked to cortical and subcortical regions, respectively. Thus, cortical and subcortical memory regions exhibit distinct genetic signatures that potentially reflect functional differences in health and disease, and nominates gene candidates for future experimental investigations.||URI:||https://hdl.handle.net/10356/148709||ISSN:||2373-2822||DOI:||10.1523/ENEURO.0283-19.2019||Rights:||© 2019 The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
|Appears in Collections:||SSS Journal Articles|
Updated on Jan 19, 2022
Updated on Jan 19, 2022
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