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Title: Biomimetic vs. direct approach to deposit hydroxyapatite on the surface of low melting point polymers for tissue engineering
Authors: Riau, Andri Kartasasmita
Venkatraman, Subbu S.
Mehta, Jodhbir Singh
Keywords: Engineering::Materials
Issue Date: 2020
Source: Riau, A. K., Venkatraman, S. S. & Mehta, J. S. (2020). Biomimetic vs. direct approach to deposit hydroxyapatite on the surface of low melting point polymers for tissue engineering. Nanomaterials, 10(11).
Journal: Nanomaterials
Abstract: Polymers are widely used in many applications in the field of biomedical engineering. Among eclectic selections of polymers, those with low melting temperature (Tm < 200 °C), such as poly(methyl methacrylate), poly(lactic-co-glycolic acid), or polyethylene, are often used in bone, dental, maxillofacial, and corneal tissue engineering as substrates or scaffolds. These polymers, however, are bioinert, have a lack of reactive surface functional groups, and have poor wettability, affecting their ability to promote cellular functions and biointegration with the surrounding tissue. Improving the biointegration can be achieved by depositing hydroxyapatite (HAp) on the polymeric substrates. Conventional thermal spray and vapor phase coating, including the Food and Drug Administration (FDA)-approved plasma spray technique, is not suitable for application on the low Tm polymers due to the high processing temperature, reaching more than 1000 °C. Two non-thermal HAp coating approaches have been described in the literature, namely, the biomimetic deposition and direct nanoparticle immobilization techniques. In the current review, we elaborate on the unique features of each technique, followed by discussing the advantages and disadvantages of each technique to help readers decide on which method is more suitable for their intended applications. Finally, the future perspectives of the non-thermal HAp coating are given in the conclusion.
ISSN: 2079-4991
DOI: 10.3390/nano10112162
Rights: © 2020 The Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
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