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Title: Enhanced sample pre-concentration by ion concentration polarization on a paraffin coated converging microfluidic paper based analytical platform
Authors: Perera, A. T. K.
Phan, Dinh-Tuan
Pudasaini, Sanam
Liu, Yu
Yang, Chun
Keywords: Engineering::Mechanical engineering
Issue Date: 2020
Source: Perera, A. T. K., Phan, D., Pudasaini, S., Liu, Y. & Yang, C. (2020). Enhanced sample pre-concentration by ion concentration polarization on a paraffin coated converging microfluidic paper based analytical platform. Biomicrofluidics, 14(1).
Project: RG83/15
Journal: Biomicrofluidics
Abstract: Microfluidic paper-based analytical devices (μPADs) represent a modest and feasible alternative for conventional analytical methods. However, the inadequate sensitivity of these devices limits the possible applications of μPADs. In this scenario, inducing ion concentration polarization (ICP) on μPADs has shown promise to overcome this limitation by preconcentrating the analytes of interest. Here, we report a μPAD implementing ICP using an off-shelf Nafion® membrane as the perm selective membrane. Two types of devices with a geometrical configuration of a straight channel converging at the middle connecting to circular reservoirs at the end of channels were fabricated. The devices are comprised of a single input channel and an absorption channel. The Nafion membrane is attached to the absorption channel of the device, which is encased by heating with paraffin films at both sides to lower the electro-osmotic flow generated by an applied DC electric field that is needed for ICP. The field induced ICP enables obtaining a maximum concentration factor of more than 2000 folds for fluorescein sodium salt solution on the μPAD. Also, since evaporation of the sample solution was reported to be of great influence on the concentration factor, we analyze the effect of sample solution evaporation on sample preconcentration. Furthermore, our reported fabrication method for μPAD can lower the fabrication cost down to 0.3 USD. This device shows the potential to be developed for serving as a diagnostic and environmental monitoring platform.
ISSN: 1932-1058
DOI: 10.1063/1.5133946
Rights: © 2020 The Author(s). All rights reserved. This paper was published by American Institute of Physics (AIP) in Applied Physics Reviews and is made available with permission of The Author(s).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MAE Journal Articles

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