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Title: Optical coherence tomography angiography in diabetes and diabetic retinopathy
Authors: Chua, Jacqueline
Sim, Ralene
Tan, Bingyao
Wong, Damon Wing Kee
Yao, Xinwen
Liu, Xinyu
Ting, Daniel Shu Wei
Schmidl, Doreen
Ang, Marcus
Garhöfer, Gerhard
Schmetterer, Leopold
Keywords: Science::Biological sciences
Issue Date: 2020
Source: Chua, J., Sim, R., Tan, B., Wong, D. W. K., Yao, X., Liu, X., Ting, D. S. W., Schmidl, D., Ang, M., Garhöfer, G. & Schmetterer, L. (2020). Optical coherence tomography angiography in diabetes and diabetic retinopathy. Journal of Clinical Medicine, 9(6), 1723-.
Project: CG/C010A/2017
Journal: Journal of Clinical Medicine
Abstract: Diabetic retinopathy (DR) is a common complication of diabetes mellitus that disrupts the retinal microvasculature and is a leading cause of vision loss globally. Recently, optical coherence tomography angiography (OCTA) has been developed to image the retinal microvasculature, by generating 3-dimensional images based on the motion contrast of circulating blood cells. OCTA offers numerous benefits over traditional fluorescein angiography in visualizing the retinal vasculature in that it is non-invasive and safer; while its depth-resolved ability makes it possible to visualize the finer capillaries of the retinal capillary plexuses and choriocapillaris. High-quality OCTA images have also enabled the visualization of features associated with DR, including microaneurysms and neovascularization and the quantification of alterations in retinal capillary and choriocapillaris, thereby suggesting a promising role for OCTA as an objective technology for accurate DR classification. Of interest is the potential of OCTA to examine the effect of DR on individual retinal layers, and to detect DR even before it is clinically detectable on fundus examination. We will focus the review on the clinical applicability of OCTA derived quantitative metrics that appear to be clinically relevant to the diagnosis, classification, and management of patients with diabetes or DR. Future studies with longitudinal design of multiethnic multicenter populations, as well as the inclusion of pertinent systemic information that may affect vascular changes, will improve our understanding on the benefit of OCTA biomarkers in the detection and progression of DR.
ISSN: 2077-0383
DOI: 10.3390/jcm9061723
Rights: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution(CC BY) license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
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