Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/148895
Title: PTEN in hereditary and sporadic cancer
Authors: Ngeow, Joanne
Eng, Charis
Keywords: Science::Medicine
Issue Date: 2020
Source: Ngeow, J. & Eng, C. (2020). PTEN in hereditary and sporadic cancer. Cold Spring Harbor Perspectives in Medicine, 10(4), a036087-. https://dx.doi.org/10.1101/cshperspect.a036087
Journal: Cold Spring Harbor Perspectives in Medicine
Abstract: Germline pathogenic phosphatase and tensin homolog (PTEN) mutations cause PTEN hamartoma tumor syndrome (PHTS), characterized by various benign and malignant tumors of the thyroid, breast, endometrium, and other organs. Patients with PHTS may present with other clinical features such as macrocephaly, intestinal polyposis, cognitive changes, and pathognomonic skin changes. Clinically, deregulation of PTEN function is implicated in other human diseases in addition to many types of human cancer. PTEN is an important phosphatase that counteracts one of the most critical cancer pathways: the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathways. Although PTEN can dephosphorylate lipids and proteins, it also has functions independent of phosphatase activity in normal and pathological states. It is positively and negatively regulated at the transcriptional level as well as posttranslationally by phosphorylation, ubiquitylation, oxidation, and acetylation. Although most of its tumor-suppressor activity is likely to be caused by lipid dephosphorylation at the plasma membrane, PTEN also resides in the cytoplasm and nucleus, and its subcellular distribution is under strict control. In this review, we highlight our current knowledge of PTEN function and recent discoveries in understanding PTEN function regulation and how this can be exploited therapeutically for cancer treatment.
URI: https://hdl.handle.net/10356/148895
ISSN: 2157-1422
DOI: 10.1101/cshperspect.a036087
Rights: © 2020 The Author(s) (published by Cold Spring Harbor Laboratory Press). This is an open-access article distributed under the terms of the Creative Commons Attribution License.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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