Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorvan Velzen, Laura S.en_US
dc.contributor.authorKelly, Sineaden_US
dc.contributor.authorIsaev, Dmitryen_US
dc.contributor.authorAleman, Andreen_US
dc.contributor.authorAftanas, Lyubomir Ien_US
dc.contributor.authorBauer, Jochenen_US
dc.contributor.authorBaune, Bernhard T.en_US
dc.contributor.authorBrak, Ivan V.en_US
dc.contributor.authorCarballedo, Angelaen_US
dc.contributor.authorConnolly, Colm G.en_US
dc.contributor.authorCouvy-Duchesne, Baptisteen_US
dc.contributor.authorCullen, Kathryn Ren_US
dc.contributor.authorDanilenko, Konstantin Ven_US
dc.contributor.authorDannlowski, Udoen_US
dc.contributor.authorEnneking, Verenaen_US
dc.contributor.authorFilimonova, Elenaen_US
dc.contributor.authorFörster, Katharinaen_US
dc.contributor.authorFrodl, Thomasen_US
dc.contributor.authorGotlib, Ian H.en_US
dc.contributor.authorGroenewold, Nynke A.en_US
dc.contributor.authorGrotegerd, Dominiken_US
dc.contributor.authorHarris, Mathew A.en_US
dc.contributor.authorHatton, Sean N.en_US
dc.contributor.authorHawkins, Emma L.en_US
dc.contributor.authorHickie, Ian B.en_US
dc.contributor.authorHo, Tiffany C.en_US
dc.contributor.authorJansen, Andreasen_US
dc.contributor.authorKircher, Tiloen_US
dc.contributor.authorKlimes-Dougan, Bonnieen_US
dc.contributor.authorKochunov, Peteren_US
dc.contributor.authorKrug, Axelen_US
dc.contributor.authorLagopoulos, Jimen_US
dc.contributor.authorLee, Renicken_US
dc.contributor.authorLett, Tristram A.en_US
dc.contributor.authorLi, Mengen_US
dc.contributor.authorMacMaster, Frank P.en_US
dc.contributor.authorMartin, Nicholas G.en_US
dc.contributor.authorMcIntosh, Andrew M.en_US
dc.contributor.authorMcLellan, Quinnen_US
dc.contributor.authorMeinert, Susanneen_US
dc.contributor.authorNenadić, Igoren_US
dc.contributor.authorOsipov, Evgenyen_US
dc.contributor.authorPenninx, Brenda W. J. H.en_US
dc.contributor.authorPortella, Maria J.en_US
dc.contributor.authorRepple, Jonathanen_US
dc.contributor.authorRoos, Annerineen_US
dc.contributor.authorSacchet, Matthew D.en_US
dc.contributor.authorSämann, Philipp G.en_US
dc.contributor.authorSchnell, Knuten_US
dc.contributor.authorShen, Xueyien_US
dc.contributor.authorSim, Kangen_US
dc.contributor.authorStein, Dan J.en_US
dc.contributor.authorvan Tol, Marie-Joseen_US
dc.contributor.authorTomyshev, Alexander S.en_US
dc.contributor.authorTozzi, Leonardoen_US
dc.contributor.authorVeer, Ilya M.en_US
dc.contributor.authorVermeiren, Roberten_US
dc.contributor.authorVives-Gilabert, Yolandaen_US
dc.contributor.authorWalter, Henriken_US
dc.contributor.authorWalter, Martinen_US
dc.contributor.authorvan der Wee, Nic J. A.en_US
dc.contributor.authorvan der Werff, Steven J. A.en_US
dc.contributor.authorSchreiner, Melinda Westlunden_US
dc.contributor.authorWhalley, Heather C.en_US
dc.contributor.authorWright, Margaret J.en_US
dc.contributor.authorYang, Tony T.en_US
dc.contributor.authorZhu, Alyssaen_US
dc.contributor.authorVeltman, Dick J.en_US
dc.contributor.authorThompson, Paul M.en_US
dc.contributor.authorJahanshad, Nedaen_US
dc.contributor.authorSchmaal, Lianneen_US
dc.identifier.citationvan Velzen, L. S., Kelly, S., Isaev, D., Aleman, A., Aftanas, L. I., Bauer, J., Baune, B. T., Brak, I. V., Carballedo, A., Connolly, C. G., Couvy-Duchesne, B., Cullen, K. R., Danilenko, K. V., Dannlowski, U., Enneking, V., Filimonova, E., Förster, K., Frodl, T., Gotlib, I. H., ...Schmaal, L. (2019). White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group. Molecular Psychiatry, 25(7), 1511-1525.
dc.description.abstractAlterations in white matter (WM) microstructure have been implicated in the pathophysiology of major depressive disorder (MDD). However, previous findings have been inconsistent, partially due to low statistical power and the heterogeneity of depression. In the largest multi-site study to date, we examined WM anisotropy and diffusivity in 1305 MDD patients and 1602 healthy controls (age range 12-88 years) from 20 samples worldwide, which included both adults and adolescents, within the MDD Working Group of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) consortium. Processing of diffusion tensor imaging (DTI) data and statistical analyses were harmonized across sites and effects were meta-analyzed across studies. We observed subtle, but widespread, lower fractional anisotropy (FA) in adult MDD patients compared with controls in 16 out of 25 WM tracts of interest (Cohen's d between 0.12 and 0.26). The largest differences were observed in the corpus callosum and corona radiata. Widespread higher radial diffusivity (RD) was also observed (all Cohen's d between 0.12 and 0.18). Findings appeared to be driven by patients with recurrent MDD and an adult age of onset of depression. White matter microstructural differences in a smaller sample of adolescent MDD patients and controls did not survive correction for multiple testing. In this coordinated and harmonized multisite DTI study, we showed subtle, but widespread differences in WM microstructure in adult MDD, which may suggest structural disconnectivity in MDD.en_US
dc.relation.ispartofMolecular Psychiatryen_US
dc.rights© The Author(s) 2019. This article is published with open access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons. org/licenses/by/4.0/.en_US
dc.titleWhite matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working groupen_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.description.versionPublished versionen_US
item.fulltextWith Fulltext-
Appears in Collections:LKCMedicine Journal Articles

Page view(s)

Updated on Jun 27, 2022


Updated on Jun 27, 2022

Google ScholarTM




Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.