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Title: White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group
Authors: van Velzen, Laura S.
Kelly, Sinead
Isaev, Dmitry
Aleman, Andre
Aftanas, Lyubomir I
Bauer, Jochen
Baune, Bernhard T.
Brak, Ivan V.
Carballedo, Angela
Connolly, Colm G.
Couvy-Duchesne, Baptiste
Cullen, Kathryn R
Danilenko, Konstantin V
Dannlowski, Udo
Enneking, Verena
Filimonova, Elena
Förster, Katharina
Frodl, Thomas
Gotlib, Ian H.
Groenewold, Nynke A.
Grotegerd, Dominik
Harris, Mathew A.
Hatton, Sean N.
Hawkins, Emma L.
Hickie, Ian B.
Ho, Tiffany C.
Jansen, Andreas
Kircher, Tilo
Klimes-Dougan, Bonnie
Kochunov, Peter
Krug, Axel
Lagopoulos, Jim
Lee, Renick
Lett, Tristram A.
Li, Meng
MacMaster, Frank P.
Martin, Nicholas G.
McIntosh, Andrew M.
McLellan, Quinn
Meinert, Susanne
Nenadić, Igor
Osipov, Evgeny
Penninx, Brenda W. J. H.
Portella, Maria J.
Repple, Jonathan
Roos, Annerine
Sacchet, Matthew D.
Sämann, Philipp G.
Schnell, Knut
Shen, Xueyi
Sim, Kang
Stein, Dan J.
van Tol, Marie-Jose
Tomyshev, Alexander S.
Tozzi, Leonardo
Veer, Ilya M.
Vermeiren, Robert
Vives-Gilabert, Yolanda
Walter, Henrik
Walter, Martin
van der Wee, Nic J. A.
van der Werff, Steven J. A.
Schreiner, Melinda Westlund
Whalley, Heather C.
Wright, Margaret J.
Yang, Tony T.
Zhu, Alyssa
Veltman, Dick J.
Thompson, Paul M.
Jahanshad, Neda
Schmaal, Lianne
Keywords: Science::Medicine
Issue Date: 2019
Source: van Velzen, L. S., Kelly, S., Isaev, D., Aleman, A., Aftanas, L. I., Bauer, J., Baune, B. T., Brak, I. V., Carballedo, A., Connolly, C. G., Couvy-Duchesne, B., Cullen, K. R., Danilenko, K. V., Dannlowski, U., Enneking, V., Filimonova, E., Förster, K., Frodl, T., Gotlib, I. H., ...Schmaal, L. (2019). White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group. Molecular Psychiatry, 25(7), 1511-1525.
Journal: Molecular Psychiatry
Abstract: Alterations in white matter (WM) microstructure have been implicated in the pathophysiology of major depressive disorder (MDD). However, previous findings have been inconsistent, partially due to low statistical power and the heterogeneity of depression. In the largest multi-site study to date, we examined WM anisotropy and diffusivity in 1305 MDD patients and 1602 healthy controls (age range 12-88 years) from 20 samples worldwide, which included both adults and adolescents, within the MDD Working Group of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) consortium. Processing of diffusion tensor imaging (DTI) data and statistical analyses were harmonized across sites and effects were meta-analyzed across studies. We observed subtle, but widespread, lower fractional anisotropy (FA) in adult MDD patients compared with controls in 16 out of 25 WM tracts of interest (Cohen's d between 0.12 and 0.26). The largest differences were observed in the corpus callosum and corona radiata. Widespread higher radial diffusivity (RD) was also observed (all Cohen's d between 0.12 and 0.18). Findings appeared to be driven by patients with recurrent MDD and an adult age of onset of depression. White matter microstructural differences in a smaller sample of adolescent MDD patients and controls did not survive correction for multiple testing. In this coordinated and harmonized multisite DTI study, we showed subtle, but widespread differences in WM microstructure in adult MDD, which may suggest structural disconnectivity in MDD.
ISSN: 1359-4184
DOI: 10.1038/s41380-019-0477-2
Rights: © The Author(s) 2019. This article is published with open access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons. org/licenses/by/4.0/.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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