Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/149031
Title: A peptidoglycan storm caused by β-lactam antibiotic's action on host microbiota drives Candida albicans infection
Authors: Tan, Chew Teng
Xu, Xiaoli
Qiao, Yuan
Wang, Yue
Keywords: Science
Issue Date: 2021
Source: Tan, C. T., Xu, X., Qiao, Y. & Wang, Y. (2021). A peptidoglycan storm caused by β-lactam antibiotic's action on host microbiota drives Candida albicans infection. Nature Communications, 12(1), 2560-. https://dx.doi.org/10.1038/s41467-021-22845-2
Journal: Nature Communications
Abstract: The commensal fungus Candida albicans often causes life-threatening infections in patients who are immunocompromised with high mortality. A prominent but poorly understood risk factor for the C. albicans commensal‒pathogen transition is the use of broad-spectrum antibiotics. Here, we report that β-lactam antibiotics cause bacteria to release significant quantities of peptidoglycan fragments that potently induce the invasive hyphal growth of C. albicans. We identify several active peptidoglycan subunits, including tracheal cytotoxin, a molecule produced by many Gram-negative bacteria, and fragments purified from the cell wall of Gram-positive Staphylococcus aureus. Feeding mice with β-lactam antibiotics causes a peptidoglycan storm that transforms the gut from a niche usually restraining C. albicans in the commensal state to promoting invasive growth, leading to systemic dissemination. Our findings reveal a mechanism underlying a significant risk factor for C. albicans infection, which could inform clinicians regarding future antibiotic selection to minimize this deadly disease incidence.
URI: https://hdl.handle.net/10356/149031
ISSN: 2041-1723
DOI: 10.1038/s41467-021-22845-2
Rights: © 2021 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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