Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/149031
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dc.contributor.authorTan, Chew Tengen_US
dc.contributor.authorXu, Xiaolien_US
dc.contributor.authorQiao, Yuanen_US
dc.contributor.authorWang, Yueen_US
dc.date.accessioned2021-05-21T01:30:00Z-
dc.date.available2021-05-21T01:30:00Z-
dc.date.issued2021-
dc.identifier.citationTan, C. T., Xu, X., Qiao, Y. & Wang, Y. (2021). A peptidoglycan storm caused by β-lactam antibiotic's action on host microbiota drives Candida albicans infection. Nature Communications, 12(1), 2560-. https://dx.doi.org/10.1038/s41467-021-22845-2en_US
dc.identifier.issn2041-1723en_US
dc.identifier.urihttps://hdl.handle.net/10356/149031-
dc.description.abstractThe commensal fungus Candida albicans often causes life-threatening infections in patients who are immunocompromised with high mortality. A prominent but poorly understood risk factor for the C. albicans commensal‒pathogen transition is the use of broad-spectrum antibiotics. Here, we report that β-lactam antibiotics cause bacteria to release significant quantities of peptidoglycan fragments that potently induce the invasive hyphal growth of C. albicans. We identify several active peptidoglycan subunits, including tracheal cytotoxin, a molecule produced by many Gram-negative bacteria, and fragments purified from the cell wall of Gram-positive Staphylococcus aureus. Feeding mice with β-lactam antibiotics causes a peptidoglycan storm that transforms the gut from a niche usually restraining C. albicans in the commensal state to promoting invasive growth, leading to systemic dissemination. Our findings reveal a mechanism underlying a significant risk factor for C. albicans infection, which could inform clinicians regarding future antibiotic selection to minimize this deadly disease incidence.en_US
dc.description.sponsorshipNational Medical Research Council (NMRC)en_US
dc.language.isoenen_US
dc.relation.ispartofNature Communicationsen_US
dc.rights© 2021 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en_US
dc.subjectScienceen_US
dc.titleA peptidoglycan storm caused by β-lactam antibiotic's action on host microbiota drives Candida albicans infectionen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.identifier.doi10.1038/s41467-021-22845-2-
dc.description.versionPublished versionen_US
dc.identifier.pmid33963193-
dc.identifier.issue1en_US
dc.identifier.volume12en_US
dc.identifier.spage2560en_US
dc.subject.keywordsCandida Albicansen_US
dc.subject.keywordsMicrobiotaen_US
item.grantfulltextopen-
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