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Title: Evidence for cross-protection against subsequent febrile respiratory illness episodes from prior infections by different viruses among Singapore military recruits 2009-2014
Authors: Chen, Mark I-Cheng
Loh, Jin Phang
Chuah, Cheryl X. P.
Gao, Christine Qiu Han
Sun, Yinxiaohe
Ng, Sock Hoon
Koh, Victor Wee-Hong
Goh, Ee Hui
Zhao, Xiahong
Tambyah, Paul Anantharajah
Cook, Alex R.
Chng, Jeremiah
Pang, Junxiong
Tan, Boon Huan
Lee, Vernon J.
Keywords: Science::Medicine
Issue Date: 2019
Source: Chen, M. I., Loh, J. P., Chuah, C. X. P., Gao, C. Q. H., Sun, Y., Ng, S. H., Koh, V. W., Goh, E. H., Zhao, X., Tambyah, P. A., Cook, A. R., Chng, J., Pang, J., Tan, B. H. & Lee, V. J. (2019). Evidence for cross-protection against subsequent febrile respiratory illness episodes from prior infections by different viruses among Singapore military recruits 2009-2014. Journal of Infectious Diseases, 219(12), 1913-1923.
Project: R-608-000-132-112
Journal: Journal of Infectious Diseases
Abstract: Background: Few studies have evaluated the relative cross-protection conferred by infection with different groups of viruses through studies of sequential infections in humans. We investigated the presence of short-lived relative cross-protection conferred by specific prior viral infections against subsequent febrile respiratory illness (FRI). Methods: Men enlisted in basic military training between December 2009 and December 2014 were recruited, with the first FRI as the study entry point. ResPlex II assays and real-time polymerase chain reaction assays were used to detect viral pathogens in nasal wash samples, and survival analyses were performed to determine whether infection with particular viruses conferred short-lived relative cross-protection against FRI. Results: Prior infection with adenovirus (hazard ratio [HR], 0.24; 95% confidence interval [CI], .14–.44) or influenza virus (HR, 0.52; 95% CI, .38–.73) conferred relative protection against subsequent FRI episode. Results were statistically significant even after adjustment for the interval between enlistment and FRI (P < .001). Adenovirus-positive participants with FRI episodes tended to be protected against subsequent infection with adenovirus, coronavirus, enterovirus/rhinovirus, and influenza virus (P = .062–.093), while men with influenza virus–positive FRI episodes tended be protected against subsequent infection with adenovirus (P = .044) and influenza virus (P = .081). Conclusion: Prior adenovirus or influenza virus infection conferred cross-protection against subsequent FRI episodes relative to prior infection due to other circulating viruses.
ISSN: 0022-1899
DOI: 10.1093/infdis/jiz046
Rights: © 2019 The Author(s). Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence ( by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact DOI: 10.1093/infdis/jiz046
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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