Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/149214
Title: Predicting real-world functioning in schizophrenia : the relative contributions of neurocognition, functional capacity, and negative symptoms
Authors: Yang, Zixu
Lee, Soon Hong
Nur Amirah Abdul Rashid
See, Yuen Mei
Dauwels, Justin
Tan, Bhing Leet
Lee, Jimmy Chee Keong
Keywords: Science::General
Psychiatry
Issue Date: 2021
Source: Yang, Z., Lee, S. H., Nur Amirah Abdul Rashid, See, Y. M., Dauwels, J., Tan, B. L. & Lee, J. C. K. (2021). Predicting real-world functioning in schizophrenia : the relative contributions of neurocognition, functional capacity, and negative symptoms. Frontiers in Psychiatry, 12, 639536-. https://dx.doi.org/10.3389/fpsyt.2021.639536
Project: NMRC/CG/004/2013
M4081187.E30
Journal: Frontiers in Psychiatry
Abstract: Neurocognition and functional capacity are commonly reported predictors of real-world functioning in schizophrenia. However, the additional impact of negative symptoms, specifically its subdomains, i.e., diminished expression (DE) and avolition-apathy (AA), on real-world functioning remains unclear. The current study assessed 58 individuals with schizophrenia. Neurocognition was assessed with the Brief Assessment of Cognition in Schizophrenia, functional capacity with the UCSD Performance-based Skills Assessment (UPSA-B), and negative symptoms with the Negative Symptom Assessment-16. Real-world functioning was assessed with the Multnomah Community Ability Scale (MCAS) with employment status as an additional objective outcome. Hierarchical regressions and sequential logistic regressions were used to examine the associations between the variables of interest. The results show that global negative symptoms contribute substantial additional variance in predicting MCAS and employment status above and beyond the variance accounted for by neurocognition and functional capacity. In addition, both AA and DE predict the MCAS after controlling for cognition and functional capacity. Only AA accounts for additional variance in employment status beyond that by UPSA-B. In summary, negative symptoms contribute substantial additional variance in predicting both real-world functioning and employment outcomes after accounting for neurocognition and functional capacity. Our findings emphasize both DE and AA as important treatment targets in functional recovery for people with schizophrenia.
URI: https://hdl.handle.net/10356/149214
ISSN: 1664-0640
DOI: 10.3389/fpsyt.2021.639536
Rights: © 2021 Yang, Lee, Abdul Rashid, See, Dauwels, Tan and Lee. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:EEE Journal Articles
LKCMedicine Journal Articles

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