Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/149237
Title: Carboxylated chalcone and benzaldehyde derivatives of triosmium carbonyl clusters : synthesis, characterization and biological activity towards MCF-7 cells
Authors: Kwek, Zheng Hua
Ganguly, Rakesh
Afreen, A. Mohamed
Koh, Wei Xiang
Leong, Weng Kee
Tan, Kelvin Yong Leng
Keywords: Science::Chemistry
Science::Chemistry::Inorganic chemistry
Issue Date: 2020
Source: Kwek, Z. H., Ganguly, R., Afreen, A. M., Koh, W. X., Leong, W. K. & Tan, K. Y. L. (2020). Carboxylated chalcone and benzaldehyde derivatives of triosmium carbonyl clusters : synthesis, characterization and biological activity towards MCF-7 cells. Journal of Cluster Science, 31(4), 759-767. https://dx.doi.org/10.1007/s10876-019-01684-8
Journal: Journal of Cluster Science
Abstract: The activated cluster Os3(CO)10(CH3CN)2 (1) reacts readily with a number of carboxylated chalcones and benzaldehydes (2a−j) to afford products with the general formula Os3(CO)10(µ-H)(µ-O2CR) (3a–j). The structures of all the novel clusters have been characterized by IR and 1H NMR spectroscopy, as well as mass spectrometry and elemental analysis. Single-crystal X-ray diffraction analysis has also been carried out for one of the carboxylated chalcones and two of the derivatized clusters. The activity of some of the derivatized clusters against the ER+ breast carcinoma MCF-7 cancer cell line has also been evaluated.
URI: https://hdl.handle.net/10356/149237
ISSN: 1040-7278
DOI: 10.1007/s10876-019-01684-8
Rights: © 2019 Springer Science+Business Media. This is a post-peer-review, pre-copyedit version of an article published in Journal of Cluster Science. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10876-019-01684-8
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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