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|Title:||Septic patients with cancer : do prehospital antibiotics improve survival? A sub-analysis of the PHANTASi trial||Authors:||Panday, Rishi Nannan
Schermer, E. H.
Nanayakkara, P. W. B.
|Keywords:||Science::Medicine||Issue Date:||2020||Source:||Panday, R. N., Wang, S., Schermer, E. H., Cooksley, T., Alam, N. & Nanayakkara, P. W. B. (2020). Septic patients with cancer : do prehospital antibiotics improve survival? A sub-analysis of the PHANTASi trial. The Netherlands Journal of Medicine, 78(1), 3-9.||Journal:||The Netherlands Journal of Medicine||Abstract:||Background: Sepsis in patients with cancer is increasingly common and associated with high mortality. To date, no studies have examined the effectiveness of prehospital antibiotics in septic patients with cancer. This study aimed to compare survival of septic patients with cancer to those without and to evaluate the effect of prehospital antibiotics in septic patients with cancer. Methods: We conducted a post-hoc sub-analysis of the PHANTASi (PreHospital ANTibioitcs Against Sepsis) trial database: a randomised controlled trial which enrolled patients with suspected sepsis who were transported to the emergency department by ambulance. Patients in the intervention group were administered prehospital intravenous antibiotics while those in the control group received usual care. We compared patients who had cancer to those who did not. Primary outcome was 28-day mortality; among the secondary outcomes, we included in-hospital mortality and 90-day mortality. Results: 357(13.4%) of the 2658 included patients had cancer in the past five years, of which, 209 (58.5%) were included in the intervention and 148 (41.5%) usual care groups; 28-day mortality was significantly higher in patients who were diagnosed with cancer in the past five years than those without cancer in the past five years: 15.2% vs. 7.1%, respectively (p < 0.001). Prehospital antibiotics in the group of patients with cancer in the last five years yielded no significant effect on survival. There were however, significantly fewer 30-day readmissions (p = 0.031) in the intervention group of cancer patients (12.2% vs 5.7%). Conclusion: Prehospital antibiotics did not improve overall survival. However, there was a significant reduction in 30-day readmissions.||URI:||http://www.njmonline.nl/article_ft.php?a=2179&d=1438&i=232
|ISSN:||0300-2977||Schools:||Lee Kong Chian School of Medicine (LKCMedicine)||Research Centres:||Centre for Population Health Sciences||Rights:||© 2020 MacChain. All rights reserved. This paper was published in The Netherlands Journal of Medicine and is made available with permission of MacChain.||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
|Appears in Collections:||LKCMedicine Journal Articles|
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Updated on Jun 6, 2023
Updated on Jun 6, 2023
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