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Title: Association of lung function with overall mortality is independent of inflammatory, cardiac, and functional biomarkers in older adults : the ActiFE-study
Authors: Weinmayr, Gudrun
Schulz, Holger
Klenk, Jochen
Denkinger, Michael
Duran-Tauleria, Enric
Koenig, Wolfgang
Dallmeier, Dhayana
Rothenbacher, Dietrich
Boehm, Bernhard Otto
Keywords: Science::Medicine
Issue Date: 2020
Source: Weinmayr, G., Schulz, H., Klenk, J., Denkinger, M., Duran-Tauleria, E., Koenig, W., Dallmeier, D., Rothenbacher, D. & Boehm, B. O. (2020). Association of lung function with overall mortality is independent of inflammatory, cardiac, and functional biomarkers in older adults : the ActiFE-study. Scientific Reports, 10(1).
Journal: Scientific Reports
Abstract: Reduced lung function is associated with overall and cardiovascular mortality. Chronic low grade systemic inflammation is linked to impaired lung function and cardiovascular outcomes. We assessed the association of lung function with overall 8-year mortality in 867 individuals of the Activity and Function in the Elderly study using confounder-adjusted Cox proportional hazards models (including gait speed and daily walking time as measures of physical function) without and with adjustment for inflammatory and cardiac markers. Forced expiratory volume in 1 s/forced vital capacity (FEV 1 / FVC) but not FVC was related to mortality after adjustment for physical function and other confounders. Additional adjustment for inflammatory and cardiac markers did not change the hazard ratios (HR) markedly, e.g. for a FEV 1 / FVC below 0.7 from 1.55 [95% confidence-interval (CI) 1.14 - 2.11] to 1.49 (95% CI 1.09 - 2.03). These independent associations were also observed in the apparently lung healthy subpopulation with even higher HRs up to 2.76 (95% CI 1.52 - 4.93). A measure of airflow limitation but not vital capacity was associated with overall mortality in this community-dwelling older population and in the subgroup classified as lung healthy. These associations were independent of adjustment for inflammatory and cardiac markers and support the role of airflow limitation as independent predictor of mortality in older adults.
ISSN: 2045-2322
DOI: 10.1038/s41598-020-68372-w
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: © 2020 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
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