Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/149750
Title: Construction of a G-quadruplex-specific DNA endonuclease
Authors: Dang, Dung Thanh
Nguyen, Le Tuan Anh
Truong, Tuom Tinh Thi
Nguyen, Hoang Duc
Phan, Anh Tuân
Keywords: Science::Biological sciences::Molecular biology
Science::Chemistry::Biochemistry
Issue Date: 2021
Source: Dang, D. T., Nguyen, L. T. A., Truong, T. T. T., Nguyen, H. D. & Phan, A. T. (2021). Construction of a G-quadruplex-specific DNA endonuclease. Chemical Communications, 57(37), 4568-4571. https://dx.doi.org/10.1039/d0cc05890d
Project: MOE2018-T2-2-029
Journal: Chemical Communications 
Abstract: We generated a novel G-quadruplex (G4)-specific endonuclease by fusing a G4 recognition domain of the RHAU helicase with a cleavage domain of the Fok1 nuclease. The fusion protein can specifically bind a parallel G4 and cleave a double-stranded DNA (dsDNA) next to it. The new endonuclease could be used to detect a G4 in a long dsDNA, providing a useful tool for mapping the formation of G4s in the genome.
URI: https://hdl.handle.net/10356/149750
ISSN: 1359-7345
DOI: 10.1039/d0cc05890d
Rights: © 2021 The Author(s) (Royal Society of Chemistry). All rights reserved. This paper was published in Chemical Communications and is made available with permission of The Author(s) (Royal Society of Chemistry).
Fulltext Permission: embargo_20220412
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

Files in This Item:
File Description SizeFormat 
Construction of a G-quadruplex-specific DNA endonuclease.pdf
  Until 2022-04-12
386.55 kBAdobe PDFUnder embargo until Apr 12, 2022

Page view(s)

112
Updated on Jan 18, 2022

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.