Please use this identifier to cite or link to this item:
Title: A novel minimal motif for left-handed G-quadruplex formation
Authors: Das, Poulomi
Winnerdy, Fernaldo Richtia
Maity, Arijit
Mechulam, Yves
Phan, Anh Tuân
Keywords: Science::Chemistry::Biochemistry
Science::Biological sciences
Issue Date: 2021
Source: Das, P., Winnerdy, F. R., Maity, A., Mechulam, Y. & Phan, A. T. (2021). A novel minimal motif for left-handed G-quadruplex formation. Chemical Communications, 57(20), 2527-2530.
Journal: Chemical Communications 
Abstract: A recent study on the left-handed G-quadruplex (LHG4) DNA revealed a 12-nt minimal motif GTGGTGGTGGTG with the ability to independently form an LHG4 and to drive an adjacent sequence to LHG4 formation. Here we have identified a second LHG4-forming motif, GGTGGTGGTGTG, and determined the X-ray crystal structure of an LHG4 involving this motif. Our structural analysis indicated the role of split guanines and single thymine loops in promoting LHG4 formation.
ISSN: 1359-7345
DOI: 10.1039/d0cc08146a
Rights: © 2021 The Author(s) (Royal Society of Chemistry). All rights reserved. This paper was published in Chemical Communications and is made available with permission of The Author(s) (Royal Society of Chemistry).
Fulltext Permission: embargo_20220130
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

Files in This Item:
File Description SizeFormat 
A novel minimal motif for left-handed G-quadruplex formation .pdf
  Until 2022-01-30
420.61 kBAdobe PDFUnder embargo until Jan 30, 2022

Page view(s)

Updated on Jul 26, 2021

Google ScholarTM




Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.