Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/150064
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dc.contributor.authorBao, Chaolemengen_US
dc.contributor.authorChong, Mark S. K.en_US
dc.contributor.authorQin, Leien_US
dc.contributor.authorFan, Yipingen_US
dc.contributor.authorTeo, Erin Yilingen_US
dc.contributor.authorSandikin, Dedyen_US
dc.contributor.authorChoolani, Maheshen_US
dc.contributor.authorChan, Jerry Kok Yenen_US
dc.date.accessioned2021-06-04T03:45:26Z-
dc.date.available2021-06-04T03:45:26Z-
dc.date.issued2019-
dc.identifier.citationBao, C., Chong, M. S. K., Qin, L., Fan, Y., Teo, E. Y., Sandikin, D., Choolani, M. & Chan, J. K. Y. (2019). Effects of tricalcium phosphate in polycaprolactone scaffold for mesenchymal stem cell-based bone tissue engineering. Materials Technology, 34(6), 361-367. https://dx.doi.org/10.1080/10667857.2019.1568368en_US
dc.identifier.issn1066-7857en_US
dc.identifier.other0000-0002-9586-6303-
dc.identifier.other0000-0002-6269-1519-
dc.identifier.urihttps://hdl.handle.net/10356/150064-
dc.description.abstractPolycaprolactone (PCL) – tricalcium phosphate (TCP) is an established composite material for bone tissue engineering. However, the effects of TCP inclusion in PCL for cell attachment, viability, proliferation and differentiation have not been defined. In this study, PCL and PCL - TCP scaffolds are seeded with human fetal mesenchymal stem cells (hfMSC), cultured in osteogenic differentiation medium, and cell attachment, viability, cellular proliferation, differentiation and extracellular mineral depositions were compared. Both materials allowed for good cell attachment and viability, while the final cellularity in PCL - TCP scaffolds was 1.25 - fold higher than PCL scaffolds. Mineralisation on both scaffolds was similar, after correcting for the initial calcium in the PCL - TCP scaffolds. In conclusion, the addition of 20% TCP into the macroporous PCL scaffold resulted in 1.25 - fold higher cellularity, which may be advantageous for transplantation purposes.en_US
dc.description.sponsorshipNational Medical Research Council (NMRC)en_US
dc.language.isoenen_US
dc.relationNMRC/1268/2010en_US
dc.relationNMRC/CSA-SI/0008/2016en_US
dc.relationNMRC/CSA/0059/2014en_US
dc.relation.ispartofMaterials Technologyen_US
dc.rights© 2019 Informa UK Limited, trading as Taylor & Francis Group. All rights reserved.en_US
dc.subjectEngineering::Bioengineeringen_US
dc.titleEffects of tricalcium phosphate in polycaprolactone scaffold for mesenchymal stem cell-based bone tissue engineeringen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.identifier.doi10.1080/10667857.2019.1568368-
dc.identifier.scopus2-s2.0-85062439387-
dc.identifier.issue6en_US
dc.identifier.volume34en_US
dc.identifier.spage361en_US
dc.identifier.epage367en_US
dc.subject.keywordsBone Tissue Engineeringen_US
dc.subject.keywordsMesenchymal Stem Cellen_US
dc.description.acknowledgementSingapore’s Ministry of Health’s National Medical Research Council is the funding body for this research project (NMRC/1268/2010) and provided salary support for JKYC and MC (NMRC/CSA-SI/0008/2016 & NMRC/ CSA/0059/2014 respectively.).en_US
item.fulltextNo Fulltext-
item.grantfulltextnone-
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