Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/150428
Title: Large-scale whole-genome sequencing of three diverse Asian populations in Singapore
Authors: Wu, Degang
Dou, Jinzhuang
Chai, Xiaoran
Bellis, Claire
Wilm, Andreas
Shih, Chih Chuan
Soon, Wendy Wei Jia
Bertin, Nicolas
Lin, Clarabelle Bitong
Khor, Chiea Chuen
DeGiorgio, Michael
Cheng, Shanshan
Bao, Li
Karnani, Neerja
Hwang, William Ying Khee
Davila, Sonia
Tan, Patrick
Shabbir, Asim
Moh, Angela
Tan, Eng-King
Foo, Jia Nee
Goh, Liuh Ling
Leong, Khai Pang
Foo, Roger Sik Yin
Lam, Carolyn Su Ping
Richards, Arthur Mark
Cheng, Ching-Yu
Aung, Tin
Wong, Tien Yin
Ng, Huck Hui
Liu, Jianjun
Wang, Chaolong
Keywords: Science::Medicine
Issue Date: 2019
Source: Wu, D., Dou, J., Chai, X., Bellis, C., Wilm, A., Shih, C. C., Soon, W. W. J., Bertin, N., Lin, C. B., Khor, C. C., DeGiorgio, M., Cheng, S., Bao, L., Karnani, N., Hwang, W. Y. K., Davila, S., Tan, P., Shabbir, A., Moh, A., ...Wang, C. (2019). Large-scale whole-genome sequencing of three diverse Asian populations in Singapore. Cell, 179(3), 736-749. https://dx.doi.org/10.1016/j.cell.2019.09.019
Project: IAF-PP H17/01/a0/007
SPF2014/001
SPF2013/002
SPF2014/004
SPF2014/005
CIRG/1371/2013
CIRG/1417/2015
CIRG/1488/ 2018
CSA-SI/0012/2017
CG/017/2013
CG/M006/2017_NHCS
TCR/013- NNI/2014
STaR/0011/2012
STaR2013/001
STaR/014/2013
STaR/0026/ 2015
TCR/006-NUHS/2013
TCR/012-NUHS/2014
TCR/004-NUS/2008
TCR/012-NUHS/2014
NRFF2016-03
SIGII/15203
DEB-1753489
Journal: Cell
Abstract: Underrepresentation of Asian genomes has hindered population and medical genetics research on Asians, leading to population disparities in precision medicine. By whole-genome sequencing of 4,810 Singapore Chinese, Malays, and Indians, we found 98.3 million SNPs and small insertions or deletions, over half of which are novel. Population structure analysis demonstrated great representation of Asian genetic diversity by three ethnicities in Singapore and revealed a Malay-related novel ancestry component. Furthermore, demographic inference suggested that Malays split from Chinese ∼24,800 years ago and experienced significant admixture with East Asians ∼1,700 years ago, coinciding with the Austronesian expansion. Additionally, we identified 20 candidate loci for natural selection, 14 of which harbored robust associations with complex traits and diseases. Finally, we show that our data can substantially improve genotype imputation in diverse Asian and Oceanian populations. These results highlight the value of our data as a resource to empower human genetics discovery across broad geographic regions.
URI: https://hdl.handle.net/10356/150428
ISSN: 0092-8674
DOI: 10.1016/j.cell.2019.09.019
Rights: © 2019 Elsevier Inc. All rights reserved. This paper was published in Cell and is made available with permission of Elsevier Inc.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles
SBS Journal Articles

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