Please use this identifier to cite or link to this item:
Title: Cyclization of a G4-specific peptide enhances its stability and G-quadruplex binding affinity
Authors: Ngo, Khac Huy
Yang, Renliang
Das, Poulomi
Nguyen, Giang Kien Truc
Lim, Kah Wai
Tam, James P.
Wu, Bin
Phan, Anh Tuân
Keywords: Science::Chemistry::Biochemistry
Science::Biological sciences
Issue Date: 2020
Source: Ngo, K. H., Yang, R., Das, P., Nguyen, G. K. T., Lim, K. W., Tam, J. P., Wu, B. & Phan, A. T. (2020). Cyclization of a G4-specific peptide enhances its stability and G-quadruplex binding affinity. Chemical Communications, 56(7), 1082-1084.
Project: MOE2018-T2-2-029 
Journal: Chemical Communications 
Abstract: G-quadruplexes(G4) arenon-canonical nucleicacidstructures with important implications in biology. Based on an a-helical fragment of the RHAU helicase that displays high specificity for parallelstranded G-quadrplexes, herein we demonstrate its head-to-tail cyclization by a high-efficiency ligase. The cyclic peptide exhibits superior stability and binding affinity to a G-quadruplex, and can serve as an excellent investigational tool for chemical biology applications
ISSN: 1359-7345
DOI: 10.1039/C9CC06748E
Schools: School of Physical and Mathematical Sciences 
School of Biological Sciences 
Research Centres: NTU Institute of Structural Biology 
Rights: © 2020 The Royal Society of Chemistry. All rights reserved. This paper was published in Chemical Communications and is made available with permission of The Royal Society of Chemistry.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles
SPMS Journal Articles

Files in This Item:
File Description SizeFormat 
text21_clean.pdf588.01 kBAdobe PDFThumbnail

Citations 20

Updated on Sep 26, 2023

Web of ScienceTM
Citations 20

Updated on Sep 21, 2023

Page view(s)

Updated on Sep 27, 2023

Download(s) 50

Updated on Sep 27, 2023

Google ScholarTM




Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.