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https://hdl.handle.net/10356/150540| Title: | Cyclization of a G4-specific peptide enhances its stability and G-quadruplex binding affinity | Authors: | Ngo, Khac Huy Yang, Renliang Das, Poulomi Nguyen, Giang Kien Truc Lim, Kah Wai Tam, James P. Wu, Bin Phan, Anh Tuân |
Keywords: | Science::Chemistry::Biochemistry Science::Biological sciences |
Issue Date: | 2020 | Source: | Ngo, K. H., Yang, R., Das, P., Nguyen, G. K. T., Lim, K. W., Tam, J. P., Wu, B. & Phan, A. T. (2020). Cyclization of a G4-specific peptide enhances its stability and G-quadruplex binding affinity. Chemical Communications, 56(7), 1082-1084. https://dx.doi.org/10.1039/C9CC06748E | Project: | MOE2018-T2-2-029 MOE2016-T3-1-003 |
Journal: | Chemical Communications | Abstract: | G-quadruplexes(G4) arenon-canonical nucleicacidstructures with important implications in biology. Based on an a-helical fragment of the RHAU helicase that displays high specificity for parallelstranded G-quadrplexes, herein we demonstrate its head-to-tail cyclization by a high-efficiency ligase. The cyclic peptide exhibits superior stability and binding affinity to a G-quadruplex, and can serve as an excellent investigational tool for chemical biology applications | URI: | https://hdl.handle.net/10356/150540 | ISSN: | 1359-7345 | DOI: | 10.1039/C9CC06748E | Rights: | © 2020 The Royal Society of Chemistry. All rights reserved. This paper was published in Chemical Communications and is made available with permission of The Royal Society of Chemistry. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
| Appears in Collections: | SBS Journal Articles SPMS Journal Articles |
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