Please use this identifier to cite or link to this item:
https://hdl.handle.net/10356/150540
Title: | Cyclization of a G4-specific peptide enhances its stability and G-quadruplex binding affinity | Authors: | Ngo, Khac Huy Yang, Renliang Das, Poulomi Nguyen, Giang Kien Truc Lim, Kah Wai Tam, James P. Wu, Bin Phan, Anh Tuân |
Keywords: | Science::Chemistry::Biochemistry Science::Biological sciences |
Issue Date: | 2020 | Source: | Ngo, K. H., Yang, R., Das, P., Nguyen, G. K. T., Lim, K. W., Tam, J. P., Wu, B. & Phan, A. T. (2020). Cyclization of a G4-specific peptide enhances its stability and G-quadruplex binding affinity. Chemical Communications, 56(7), 1082-1084. https://dx.doi.org/10.1039/C9CC06748E | Project: | MOE2018-T2-2-029 MOE2016-T3-1-003 |
Journal: | Chemical Communications | Abstract: | G-quadruplexes(G4) arenon-canonical nucleicacidstructures with important implications in biology. Based on an a-helical fragment of the RHAU helicase that displays high specificity for parallelstranded G-quadrplexes, herein we demonstrate its head-to-tail cyclization by a high-efficiency ligase. The cyclic peptide exhibits superior stability and binding affinity to a G-quadruplex, and can serve as an excellent investigational tool for chemical biology applications | URI: | https://hdl.handle.net/10356/150540 | ISSN: | 1359-7345 | DOI: | 10.1039/C9CC06748E | Schools: | School of Physical and Mathematical Sciences School of Biological Sciences |
Research Centres: | NTU Institute of Structural Biology | Rights: | © 2020 The Royal Society of Chemistry. All rights reserved. This paper was published in Chemical Communications and is made available with permission of The Royal Society of Chemistry. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | SBS Journal Articles SPMS Journal Articles |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
text21_clean.pdf | 588.01 kB | Adobe PDF | ![]() View/Open |
SCOPUSTM
Citations
20
19
Updated on Sep 26, 2023
Web of ScienceTM
Citations
20
19
Updated on Sep 21, 2023
Page view(s)
82
Updated on Sep 27, 2023
Download(s) 50
115
Updated on Sep 27, 2023
Google ScholarTM
Check
Altmetric
Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.