Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/150637
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dc.contributor.authorWiraja, Christianen_US
dc.contributor.authorYeo, David Chenloongen_US
dc.contributor.authorLio, Daniel Chin Shiuanen_US
dc.contributor.authorZheng, Mengjiaen_US
dc.contributor.authorXu, Chenjieen_US
dc.date.accessioned2021-06-07T08:33:07Z-
dc.date.available2021-06-07T08:33:07Z-
dc.date.issued2019-
dc.identifier.citationWiraja, C., Yeo, D. C., Lio, D. C. S., Zheng, M. & Xu, C. (2019). Functional imaging with nucleic-acid-based sensors : technology, application and future healthcare prospects. ChemBioChem, 20(4), 437-450. https://dx.doi.org/10.1002/cbic.201800430en_US
dc.identifier.issn1439-4227en_US
dc.identifier.other0000-0002-8278-3912-
dc.identifier.urihttps://hdl.handle.net/10356/150637-
dc.description.abstractTimely monitoring and assessment of human health plays a crucial role in maintaining the wellbeing of our advancing society. In addition to medical tools and devices, suitable probe agents are crucial to assist such monitoring, either in passive or active ways (i.e., sensors) through inducible signals. In this review we highlight recent developments in activatable optical sensors based on nucleic acids. Sensing mechanisms and bio-applications of these nucleic acid sensors in ex vivo assays, intracellular or in vivo settings are described. In addition, we discuss the limitations of these sensors and how nanotechnology can complement/enhance sensor properties to promote translation into clinical applications.en_US
dc.description.sponsorshipAgency for Science, Technology and Research (A*STAR)en_US
dc.description.sponsorshipNanyang Technological Universityen_US
dc.language.isoenen_US
dc.relation.ispartofChemBioChemen_US
dc.rights© 2019 Wiley-VCH Verlag GmbH &Co. KGaA, Weinhei. All rights reserved.en_US
dc.subjectEngineering::Chemical engineeringen_US
dc.titleFunctional imaging with nucleic-acid-based sensors : technology, application and future healthcare prospectsen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.contributor.researchNTU-Northwestern Institute for Nanomedicineen_US
dc.identifier.doi10.1002/cbic.201800430-
dc.identifier.pmid30230165-
dc.identifier.scopus2-s2.0-85056833915-
dc.identifier.issue4en_US
dc.identifier.volume20en_US
dc.identifier.spage437en_US
dc.identifier.epage450en_US
dc.subject.keywordsActivatable Probesen_US
dc.subject.keywordsBiosensorsen_US
dc.description.acknowledgementThis work was supported by the NTU-Northwestern Institute for Nanomedicine and Singapore A*STAR Biomedical Research Council (IAF-PP grant).en_US
item.fulltextNo Fulltext-
item.grantfulltextnone-
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