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Title: Functional imaging with nucleic-acid-based sensors : technology, application and future healthcare prospects
Authors: Wiraja, Christian
Yeo, David Chenloong
Lio, Daniel Chin Shiuan
Zheng, Mengjia
Xu, Chenjie
Keywords: Engineering::Chemical engineering
Issue Date: 2019
Source: Wiraja, C., Yeo, D. C., Lio, D. C. S., Zheng, M. & Xu, C. (2019). Functional imaging with nucleic-acid-based sensors : technology, application and future healthcare prospects. ChemBioChem, 20(4), 437-450.
Journal: ChemBioChem
Abstract: Timely monitoring and assessment of human health plays a crucial role in maintaining the wellbeing of our advancing society. In addition to medical tools and devices, suitable probe agents are crucial to assist such monitoring, either in passive or active ways (i.e., sensors) through inducible signals. In this review we highlight recent developments in activatable optical sensors based on nucleic acids. Sensing mechanisms and bio-applications of these nucleic acid sensors in ex vivo assays, intracellular or in vivo settings are described. In addition, we discuss the limitations of these sensors and how nanotechnology can complement/enhance sensor properties to promote translation into clinical applications.
ISSN: 1439-4227
DOI: 10.1002/cbic.201800430
Rights: © 2019 Wiley-VCH Verlag GmbH &Co. KGaA, Weinhei. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCBE Journal Articles

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