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Title: Rapid and controllable design of robust superwettable microchips by a click reaction for efficient o-phthalaldehyde and glucose detection
Authors: Huang, Jianying
Yang, Hui
Mao, Jiajun
Guo, Fang
Cheng, Yan
Chen, Zhong
Wang, Xiaoqin
Li, Xiao
Lai, Yuekun
Keywords: Engineering::Materials
Issue Date: 2019
Source: Huang, J., Yang, H., Mao, J., Guo, F., Cheng, Y., Chen, Z., Wang, X., Li, X. & Lai, Y. (2019). Rapid and controllable design of robust superwettable microchips by a click reaction for efficient o-phthalaldehyde and glucose detection. ACS Biomaterials Science & Engineering, 5(11), 6186-6195.
Journal: ACS Biomaterials Science & Engineering
Abstract: Superwettable patterns with superhydrophobic and superhydrophilic units have the capacity of enriching and absorbing microdroplets for multifunctional biosensing. Combining the advantages of superwettable micropatterns and a rapid click reaction, we first prepared a film using propargyl methacrylate–ethylene dimethacrylate and then created a superhydrophobic–superhydrophilic micropattern by a rapid thiol–yne click reaction. Due to the high wettability contrast, water droplets tend to be anchored in the superhydrophilic region. Molecules dissolved in a water droplet are therefore uniformly enriched in the superhydrophilic region after evaporation because of the Malangoni effect. This provides a rational strategy to develop novel patterned microchips for sensing applications. Combining with fluorescence imaging technology, the Ti superwettable microchip can be used to detect o-phthalaldehyde in water, with a detection limit as low as 10–7 mol L–1. In addition, taking advantage of the oxidative color rendering ability of glucose, the microchip, when fabricated on a glass substrate, can realize reuseable glucose detection with a detection limit of 2 mM within 15 min.
ISSN: 2373-9878
DOI: 10.1021/acsbiomaterials.9b00821
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Biomaterials Science & Engineering, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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