Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/150839
Title: Human genetic determinants of tamoxifen metabolism
Authors: Koh, Everett Chier Wei
Keywords: Science::Biological sciences::Genetics
Issue Date: 2020
Publisher: Nanyang Technological University
Source: Koh, E. C. W. (2020). Human genetic determinants of tamoxifen metabolism. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/150839
Abstract: Germline DNA variants have been found to have an impact on a diverse range of human traits, including the ability to metabolise drugs. In this study, we analysed the association between human genetic variants and serum tamoxifen metabolite levels at steady state in breast cancer patients from Singapore, Germany, and Lebanon. Our study found a strong association between a common genetic marker (rs5751245) on Chromosome 22 with log-transformed serum endoxifen levels (p=1.2 ×10^(-28)). Because CYP2D6 is a well-known metaboliser of endoxifen, we also conducted genome-wide association for CYP2D6 expression quantitative trait loci (eQTL). We found a common genetic marker (rs2413670) to be strongly associated with both endoxifen (p_endo=1.2 ×10^(-23)) and CYP2D6 eQTL (p_(CYP2D6_eQTL )=2.9 ×10^(-14)). In combination, rs5751245 and rs2413670 explain up to 30% of the variance observed in steady-state serum endoxifen levels. Our findings further contribute to our understanding of the genetic architecture of endoxifen metabolism, with the potential for translation into better outcomes for estrogen-receptor positive breast cancer patients.
URI: https://hdl.handle.net/10356/150839
DOI: 10.32657/10356/150839
Rights: This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Theses

Files in This Item:
File Description SizeFormat 
Thesis_Everett_Koh_final_correct.pdf7.83 MBAdobe PDFView/Open

Page view(s)

127
Updated on Nov 30, 2021

Download(s) 50

40
Updated on Nov 30, 2021

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.